Literature summary for 3.4.17.8 extracted from

Montealegre, M.C.; Roh, J.H.; Rae, M.; Davlieva, M.G.; Singh, K.V.; Shamoo, Y.; Murray, B.E.
Differential penicillin-binding protein 5 (PBP5) levels in the Enterococcus faecium clades with different levels of ampicillin resistance (2017), Antimicrob. Agents Chemother., 61, e02034 .

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Application

Application	Comment	Organism
medicine	PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades	Enterococcus faecium

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecium	A0A075Q0W3	-	-

Expression

Organism	Comment	Expression
Enterococcus faecium	PBP5 mRNA and protein levels are increased in subclade A1 and A2 ampicillin-resistant strains compared to those in clade B and subclade A2 ampicillin-susceptible strains. There is evidence of major clade-associated rearrangements in the region upstream of PBP5, including large DNA fragment insertions, deletions, and single nucleotide polymorphisms, that may be associated with the differential regulation of PBP5 levels between the Enterococcus faecium clades	additional information

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Release 2023.1 (January 2023)