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Literature summary for 3.4.17.8 extracted from

  • Adediran, S.A.; Kumar, I.; Pratt, R.F.
    Deacylation transition states of a bacterial DD-peptidase (2006), Biochemistry, 45, 13074-13082.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.8

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by D-lactate or D-phenyllactate Streptomyces sp.

Inhibitors

Inhibitors Comment Organism Structure
D-alpha-phenylpropionate
-
 Streptomyces sp.
D-hexahydromandelate
-
 Streptomyces sp.
D-lactate
-
 Streptomyces sp.
D-mandelate
-
 Streptomyces sp.
D-phenyllactate
-
 Streptomyces sp.
glycolyl-L-Phe
-
 Streptomyces sp.

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cleavage of the bond UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-6-carboxy-L-lysyl-D-alanyl-/-D-alanine catalytic mechanism and transition state intermediates Streptomyces sp.
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-[(ammonioacetyl)amino]-3-[[3-([2-[(1-carboxylatoethyl)amino]-1-methyl-2-oxoethyl]amino)-3-oxopropyl]sulfanyl]propanoate + H2O
-
 Streptomyces sp. ?
-
 ?
2-[(ammonioacetyl)amino]-3-[[3-([2-[(1-carboxylatoethyl)sulfanyl]-1-methyl-2-oxoethyl]amino)-3-oxopropyl]sulfanyl]propanoate + H2O
-
 Streptomyces sp. ?
-
 ?
2-[(ammonioacetyl)amino]-7-([2-[(1-carboxylatoethyl)amino]-1-methyl-2-oxoethyl]amino)-7-oxoheptanoate + H2O
-
 Streptomyces sp. ?
-
 ?
2-[[N-(phenylacetyl)alanyl]sulfanyl]propanoic acid + H2O
-
 Streptomyces sp. ?
-
 ?
3-[[N-(phenylacetyl)alanyl]oxy]benzoic acid + H2O
-
 Streptomyces sp. ?
-
 ?
3-[[N-(phenylacetyl)glycyl]oxy]benzoic acid + H2O
-
 Streptomyces sp. ?
-
 ?
additional information substrate specificity, overview Streptomyces sp. ?
-
 ?
N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. N,N'-diacetyl-L-lysyl-D-alanine + D-alanine
-
 ?

Synonyms

Synonyms Comment Organism
DD-peptidase
-
 Streptomyces sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Streptomyces sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Streptomyces sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Streptomyces sp.
7
-
 D-hexahydromandelate pH 7.5, 25°C Streptomyces sp.
11.6
-
 D-mandelate pH 7.5, 25°C Streptomyces sp.
15.5
-
 D-alpha-phenylpropionate pH 7.5, 25°C Streptomyces sp.
17.8
-
 D-phenyllactate pH 7.5, 25°C Streptomyces sp.
19.3
-
 glycolyl-L-Phe pH 7.5, 25°C Streptomyces sp.