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Literature summary for 3.4.17.3 extracted from

  • Du, X.Y.; Zabel, B.A.; Myles, T.; Allen, S.J.; Handel, T.M.; Lee, P.P.; Butcher, E.C.; Leung, L.L.
    Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets (2009), J. Biol. Chem., 284, 751-758.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
thrombin-thrombomodulin complex on the vascular endothelial surface Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DL-2-mercaptomethyl-3 guanidinoethylthiopropanoic acid specific inhibitor for CPN but not CPB Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0143
-
fibrinopeptide-beta-Lys125-133
-
Homo sapiens
0.034
-
fibrinopeptide-gamma-Lys54-62
-
Homo sapiens
0.035
-
C3a69-77 peptide derived from bradykinin Homo sapiens
0.0359
-
C3a69-77
-
Homo sapiens
0.0532
-
fibrinopeptide betaLys125-133
-
Homo sapiens
0.0706
-
bradykinin
-
Homo sapiens
0.077
-
C3a69-77 peptide derived from bradykinin Homo sapiens
0.1228
-
chemerin
-
Homo sapiens
0.143
-
fibrinopeptide betaLys125-133
-
Homo sapiens
0.17
-
chemerin
-
Homo sapiens
0.219
-
C5a66-74 peptide derived from bradykinin Homo sapiens
0.238
-
fibrinopeptide gammaLys77-85
-
Homo sapiens
0.2389
-
fibrinopeptide-gamma-Lys77-85
-
Homo sapiens
0.302
-
bradykinin
-
Homo sapiens
0.34
-
fibrinopeptide gammaLys54-62
-
Homo sapiens
0.361
-
fibrinopeptide alphaArg96-104
-
Homo sapiens
0.3614
-
fibrinopeptide-alpha-Arg96-104
-
Homo sapiens
0.448
-
fibrinopeptide alphaArg96-104
-
Homo sapiens
0.602
-
C5a66-74 peptide derived from bradykinin Homo sapiens
0.657
-
fibrinopeptide gammaLys54-62
-
Homo sapiens
0.706
-
bradykinin
-
Homo sapiens
3.727
-
fibrinopeptide gammaLys77-85
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P15169
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
blood platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
Homo sapiens ?
-
?
C3a69-77 + H2O
-
Homo sapiens ?
-
?
C3a69-77 + H2O peptide derived from bradykinin Homo sapiens ?
-
?
C5a66-74 + H2O
-
Homo sapiens ?
-
?
C5a66-74 + H2O peptide derived from bradykinin Homo sapiens ?
-
?
chemerin + H2O
-
Homo sapiens ?
-
?
chemerin + H2O CPB enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine Homo sapiens ?
-
?
chemerin + H2O CPN enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine Homo sapiens ?
-
?
fibrinopeptide alphaArg96-104 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide betaLys125-133 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide gammaLys54-62 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide gammaLys77-85 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide-alpha-Arg96-104 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide-beta-Lys125-133 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide-gamma-Lys54-62 + H2O
-
Homo sapiens ?
-
?
fibrinopeptide-gamma-Lys77-85 + H2O
-
Homo sapiens ?
-
?
prochemerin + H2O sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities Homo sapiens ?
-
?
prochemerin + H2O sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities. Endogenous CPN present in circulating plasma enhances the activity of plasmin-cleaved prochemerin Homo sapiens ?
-
?
YFPGQFAFSK + H2O bioacivity of 10-mer chemerin peptide, chemerin 149-158, is enhanced by removing the carboxyl-terminal lysine Homo sapiens YFPGQFAFS + lysine
-
?
YFPGQFAFSKALPRS + H2O sequential cleavage of prochemerin peptide, chemerin 149-163, by CPB increases chemotactic activities Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
activated thrombin-activable fibrinolysis inhibitor
-
Homo sapiens
carboxypeptidase B
-
Homo sapiens
carboxypeptidase N
-
Homo sapiens
CPB
-
Homo sapiens
CPN
-
Homo sapiens
plasma carboxypeptidase
-
Homo sapiens
TAFIa
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
activity assay Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5
-
fibrinopeptide alphaArg96-104
-
Homo sapiens
1.5
-
fibrinopeptide-alpha-Arg96-104
-
Homo sapiens
2.6
-
fibrinopeptide gammaLys54-62
-
Homo sapiens
2.6
-
fibrinopeptide-gamma-Lys54-62
-
Homo sapiens
2.7
-
chemerin
-
Homo sapiens
2.9
-
fibrinopeptide alphaArg96-104
-
Homo sapiens
3.5
-
fibrinopeptide gammaLys54-62
-
Homo sapiens
5.9
-
fibrinopeptide gammaLys77-85
-
Homo sapiens
5.9
-
fibrinopeptide-gamma-Lys77-85
-
Homo sapiens
8.4
-
C3a69-77
-
Homo sapiens
8.4
-
C3a69-77 peptide derived from bradykinin Homo sapiens
9.1
-
bradykinin
-
Homo sapiens
9.3
-
C5a66-74 peptide derived from bradykinin Homo sapiens
11.8
-
fibrinopeptide gammaLys77-85
-
Homo sapiens
13.6
-
fibrinopeptide betaLys125-133
-
Homo sapiens
13.6
-
fibrinopeptide-beta-Lys125-133
-
Homo sapiens
19.7
-
bradykinin
-
Homo sapiens
29.5
-
C5a66-74 peptide derived from bradykinin Homo sapiens
57.9
-
C3a69-77 peptide derived from bradykinin Homo sapiens
80.35
-
chemerin
-
Homo sapiens
109.1
-
fibrinopeptide betaLys125-133
-
Homo sapiens