Application | Comment | Organism |
---|---|---|
medicine | regulation of NF-kappaB and ACE2 by specific Ang II type 1 receptor AT1 and Ang II type 2 receptor AT2 antagonists in a nongenetic model of type 2 diabetic nephropathy. The AT1 receptor and AT2 receptor antagonists lead to the repression and activation of the NF-kappaB signalling pathway, respectively. The blockade of AT2 receptor leads to an increase in ACE2 expression | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | regulation of NF-kappaB and ACE2 by specific Ang II type 1 receptor AT1 and Ang II type 2 receptor AT2 antagonists in a nongenetic model of type 2 diabetic nephropathy. The AT1 receptor and AT2 receptor antagonists lead to the repression and activation of the NF-kappaB signalling pathway, respectively. The blockade of AT2 receptor leads to an increase in ACE2 expression | Rattus norvegicus |