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Literature summary for 3.4.17.23 extracted from
- Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme (2014), J. Neurosci. Res., 92, 1178-1186.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DX600 | - |
Homo sapiens |  |
| DX600 | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta protein 43 + H2O | Mus musculus | ACE2 converts amyloid-beta protein 43 to amyloid-beta protein 42 in mouse brain lysates | amyloid-beta protein 42 + ? | - |
? | |
| additional information | Mus musculus | a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
ACE2 activity shows a tendency to decrease in the serum of Alzheimer disease patients compared with normal controls | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta protein 43 + H2O | ACE2 converts amyloid-beta protein 43 to amyloid-beta protein 42 in mouse brain lysates | Mus musculus | amyloid-beta protein 42 + ? | - |
? | |
| additional information | a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40 | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE2 | - |
Mus musculus |
| ACE2 | - |
Homo sapiens |
| angiotensin converting enzyme 2 | - |
Mus musculus |
| angiotensin converting enzyme 2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | ACE2 activity shows a tendency to decrease in the serum of Alzheimer disease patients compared with normal controls | Homo sapiens |
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Release 2023.1 (January 2023)
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