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Literature summary for 3.4.17.23 extracted from

  • Masson, R.; Nicklin, S.A.; Craig, M.A.; McBride, M.; Gilday, K.; Gregorevic, P.; Allen, J.M.; Chamberlain, J.S.; Smith, G.; Graham, D.; Dominiczak, A.F.; Napoli, C.; Baker, A.H.
    Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 (2009), Hypertension, 53, 694-700.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats, gene expression profiling, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information ACE2 overexpression leads to markedly increased myocyte volume, assessed in primary rabbit myocytes Oryctolagus cuniculus
additional information overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats mediates onset of experimental severe cardiac fibrosis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus
-
angiotensin(1-7) + L-Phe
-
?
angiotensin II + H2O Oryctolagus cuniculus
-
angiotensin(1-7) + L-Phe
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Oryctolagus cuniculus
-
heart
-
Rattus norvegicus
-
heart
-
Oryctolagus cuniculus
-
myocardium
-
Rattus norvegicus
-
myocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Rattus norvegicus angiotensin(1-7) + L-Phe
-
?
angiotensin II + H2O
-
Oryctolagus cuniculus angiotensin(1-7) + L-Phe
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Oryctolagus cuniculus

General Information

General Information Comment Organism
physiological function role of ACE2 in the regulation of cardiac structure and function, as well as maintenance of systemic blood pressure, overview Oryctolagus cuniculus