Literature summary for 3.4.17.23 extracted from

Bindom, S.M.; Lazartigues, E.
The sweeter side of ACE2: physiological evidence for a role in diabetes (2009), Mol. Cell. Endocrinol., 302, 193-202.

Search for more literature for 3.4.17.23

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17	Homo sapiens	5737	-
membrane	ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17	Homo sapiens	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc metalloprotease	Homo sapiens
Zn2+	zinc metalloprotease	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-
Rattus norvegicus	Q5EGZ1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	-	Rattus norvegicus	-
brain	-	Rattus norvegicus	-
colon	-	Homo sapiens	-
heart	-	Homo sapiens	-
kidney	localization of ACE2 in the podocytes early in the development of diabetes indicates that it may protect against podocyte loss, thus preventing the worsening glomerular injury	Homo sapiens	-
liver	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
ovary	-	Homo sapiens	-
pancreas	ACE-mediated inhibition of TGF-beta expression may prevent islet fibrosis and loss of islet function	Rattus norvegicus	-
placenta	-	Homo sapiens	-
retina	-	Homo sapiens	-
retina	-	Rattus norvegicus	-
small intestine	-	Homo sapiens	-
testis	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens
ACE2	-	Rattus norvegicus

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Release 2023.1 (January 2023)