Literature summary for 3.4.17.23 extracted from

Sluimer, J.C.; Gasc, J.M.; Hamming, I.; van Goor, H.; Michaud, A.; van den Akker, L.H.; Juetten, B.; Cleutjens, J.; Bijnens, A.P.; Corvol, P.; Daemen, M.J.; Heeneman, S.
Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions (2008), J. Pathol., 215, 273-279.

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Application

Application	Comment	Organism
medicine	differential regulation of ACE2 activity during the progression of atherosclerosis suggest that this novel molecule of the reninangiotensin system may play a role in the pathogenesis of atherosclerosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	non-diseased mammary arteries and atherosclerotic carotid arteries. Total vessel wall expression of ACE and ACE2 is similar during all stages of atherosclerosis. The observed ACE2 protein is enzymatically active and activity is lower in the stable advanced atherosclerotic lesions, compared to early and ruptured atherosclerotic lesions	Homo sapiens	-
carotid atherosclerotic plaque	ACE2 mRNA is expressed in early and advanced human carotid atherosclerotic lesions	Homo sapiens	-
vein	total vessel wall expression of ACE and ACE2 is similar during all stages of atherosclerosis. The observed ACE2 protein is enzymatically active and activity is lower in the stable advanced atherosclerotic lesions, compared to early and ruptured atherosclerotic lesions	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens
angiotensin-converting enzyme 2	-	Homo sapiens

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Release 2023.1 (January 2023)