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Literature summary for 3.4.17.23 extracted from

  • Hernandez Prada, J.A.; Ferreira, A.J.; Katovich, M.J.; Shenoy, V.; Qi, Y.; Santos, R.A.; Castellano, R.K.; Lampkins, A.J.; Gubala, V.; Ostrov, D.A.; Raizada, M.K.
    Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents (2008), Hypertension, 51, 1312-1317.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
8-[[2-(dimethylamino)ethyl]amino]-5-(hydroxymethyl)-9-oxo-9H-xanthen-2-yl 4-methylbenzenesulfonate enhances ACE2 activity in a dose-dependent manner and causes considerable reductions in blood pressure and a striking reversal of cardiac and renal fibrosis in the spontaneously hypertensive rat model of hypertension Rattus norvegicus
resorcinolnaphthalein enhances ACE2 activity in a dose-dependent manner Rattus norvegicus

Application

Application Comment Organism
medicine administration of ACE2 activators may be a valid strategy for antihypertensive therapy Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q5EGZ1
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-

Synonyms

Synonyms Comment Organism
ACE2
-
Rattus norvegicus
angiotensin-converting enzyme 2
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Rattus norvegicus