Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.23 extracted from

  • Lambert, D.W.; Clarke, N.E.; Hooper, N.M.; Turner, A.J.
    Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain (2008), FEBS Lett., 582, 385-390.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-ACE2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O
-
Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys
-
?
angiotensin I + H2O
-
Homo sapiens angiotensin-(1-9) + Leu
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?
additional information the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens
angiotensin-converting enzyme-2
-
Homo sapiens