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Literature summary for 3.4.17.23 extracted from

  • Elased, K.M.; Cunha, T.S.; Gurley, S.B.; Coffman, T.M.; Morris, M.
    New mass spectrometric assay for angiotensin-converting enzyme 2 activity (2006), Hypertension, 47, 1010-1017.
    View publication on PubMed

Application

Application Comment Organism
analysis mass spectrometric assay for angiotensin-converting enzyme 2 using angiotensin II as substrate will have applications in drug screening, antagonist development, and clinical investigations Mus musculus
analysis mass spectrometric assay for angiotensin-converting enzyme 2 using angiotensin II as substrate will have applications in drug screening, antagonist development, and clinical investigations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MLN 4760 IC50: 3 nM Homo sapiens
MLN 4760 IC50: 3 nM Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
additional information no activity in plasma Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Mus musculus angiotensin-(1-7) + Phe
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?
additional information angiotensin I is not a good substrate for recombinant human ACE2 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Mus musculus
ACE2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
IC50: 3 nM Mus musculus MLN 4760
0.000003
-
IC50: 3 nM Homo sapiens MLN 4760