Application | Comment | Organism |
---|---|---|
pharmacology | design and synthesis of first potent and selective enzyme inhibitors may be useful as pharmacological tools to help understanding the biological relevance and potantial role of the enzyme in human disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-methylphenyl-benzylsuccinic acid | - |
Homo sapiens | |
3,4-dimethylphenyl-benzylsuccinic acid | - |
Homo sapiens | |
3,5-dichloro-benzylsuccinate | - |
Homo sapiens | |
3,5-dimethylphenyl-benzylsuccinic acid | - |
Homo sapiens | |
3-methylphenyl-benzylsuccinic acid | - |
Homo sapiens | |
4-methylphenyl-benzylsuccinic acid | - |
Homo sapiens | |
4-nitrophenyl-benzylsuccinic acid | - |
Homo sapiens | |
angiotensin I | - |
Homo sapiens | |
Benzylsuccinic acid | - |
Homo sapiens | |
cyclohexyl-benzylsuccinic acid | - |
Homo sapiens | |
dicyclohexyl-benzylsuccinic acid | - |
Homo sapiens | |
additional information | no inhibition by lisinopril, no inhibition by captopril, no inhibition by enalaprilat | Homo sapiens | |
phenylbenzylsuccinic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0069 | - |
angiotensin I | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | transmembrane domain | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc-binding consensus sequence HEXXH, amino acids 374-378, zinc-binding protease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Homo sapiens | - |
angiotensin-(1-9) + Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
heart ventricle | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin I + H2O | C-terminal bond between His-Leu is cleaved | Homo sapiens | angiotensin-(1-9) + Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
angiotensin-converting enzyme homologue | - |
Homo sapiens |
angiotensin-converting enzyme-related carboxypeptidase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
angiotensin I | pH 6.5, room temperature | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
angiotensin I | - |
Homo sapiens |