Literature summary for 3.4.17.22 extracted from

Hu, Z.; Zhang, H.; Haley, B.; Macchi, F.; Yang, F.; Misaghi, S.; Elich, J.; Yang, R.; Tang, Y.; Joly, J.C.; Snedecor, B.R.; Shen, A.
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells (2016), Biotechnol. Bioeng., 113, 2100-2106 .

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Application

Application	Comment	Organism
medicine	knocking out CpD gene expression provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	G3HR95	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	-	Cricetulus griseus	-

General Information

General Information	Comment	Organism
physiological function	carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese Hamster Ovary (CHO) cells	Cricetulus griseus

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Release 2023.1 (January 2023)