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Literature summary for 3.4.17.22 extracted from
- Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D (1996), J. Biol. Chem., 271, 28884-28889.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bos taurus |  |
| CdCl2 | - |
Bos taurus | |
| CuSO4 | - |
Bos taurus | |
| EDTA | - |
Bos taurus | |
| EGTA | - |
Bos taurus | |
| Guanidinoethylmercaptosuccinic acid | i.e. GEMSA | Bos taurus | |
| HgCl2 | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.042 | - |
dansyl-Phe-Leu-Arg | soluble enzyme | Bos taurus | |
| 0.052 | - |
Dansyl-Pro-Ala-Arg | membrane-bound enzyme | Bos taurus | |
| 0.053 | - |
Dansyl-Pro-Ala-Arg | soluble enzyme | Bos taurus | |
| 0.054 | - |
Dansyl-Pro-Ala-Arg | dansyl-Phe-Leu-Arg, membrane- bound enzyme | Bos taurus | |
| 0.064 | - |
Dansyl-Leu-Ala-Arg | membrane-bound enzyme | Bos taurus | |
| 0.065 | - |
Dansyl-Leu-Ala-Arg | soluble enzyme | Bos taurus | |
| 0.073 | - |
dansyl-Phe-Ala-Arg | membrane-bound enzyme | Bos taurus | |
| 0.087 | - |
dansyl-Phe-Ala-Arg | soluble enzyme | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | 19% of total activity | Bos taurus | 5829 | - |
| membrane | - |
Bos taurus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 135000 | - |
deglycosaylated enzyme | Bos taurus |
| 170000 | - |
glycosylated enzyme | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | production of growth factors and/or growth factor receptors, processing of peptide hormones | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| cerebral cortex | - |
Rattus norvegicus | - |
| corpus striatum | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| hypophysis | - |
Rattus norvegicus | - |
| hypophysis | - |
Bos taurus | - |
| hypothalamus | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| placenta | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Dansyl-Leu-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Leu-Ala + Arg | - |
? | |
| Dansyl-Phe-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Ala + Arg | - |
? | |
| Dansyl-Phe-Leu-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Leu + Arg | - |
? | |
| Dansyl-Pro-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Pro-Ala + Arg | - |
? | |
| additional information | production of growth factors and/or growth factor receptors, processing of peptide hormones | Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 6.5 | soluble enzyme | Bos taurus |
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