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Literature summary for 3.4.17.21 extracted from

  • Lapi, S.E.; Wahnishe, H.; Pham, D.; Wu, L.Y.; Nedrow-Byers, J.R.; Liu, T.; Vejdani, K.; VanBrocklin, H.F.; Berkman, C.E.; Jones, E.F.
    Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer (2009), J. Nucl. Med., 50, 2042-2048.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.21

Application

Application Comment Organism
diagnostics PSMA is a well-known imaging biomarker for staging and monitoring therapy, assessment of an 18F-labeled phosphoramidate peptidomimetic as a PSMA-targeted imaging agent for prostate cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitor in vivo distribution studies in mice bearing either PSMA-positive LNCaP or PSMA-negative PC-3 tumors, overview Homo sapiens
S-2-((2-(S-4-(4-18F-fluorobenzamido)-4-carboxybutanamido)-S-2-carboxyethoxy)hydroxyphosphorylamino)-pentanedioic acid
-
 Homo sapiens
S-2-((2-(S-4-amino-4-carboxybutanamido)-S-2-carboxyethoxy)-hydroxyphosphorylamino)-pentanedioic acid phosphoramidate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer Homo sapiens 9986
-
membrane PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
-
additional information no activity in PC-3 cells Homo sapiens
-
prostate
-
 Homo sapiens
-
prostate cancer cell PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer Homo sapiens
-

Synonyms

Synonyms Comment Organism
Prostate-specific membrane antigen
-
 Homo sapiens
PSMA
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000068
-
-
 Homo sapiens S-2-((2-(S-4-amino-4-carboxybutanamido)-S-2-carboxyethoxy)-hydroxyphosphorylamino)-pentanedioic acid
0.000014
-
-
 Homo sapiens S-2-((2-(S-4-(4-18F-fluorobenzamido)-4-carboxybutanamido)-S-2-carboxyethoxy)hydroxyphosphorylamino)-pentanedioic acid