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Literature summary for 3.4.17.21 extracted from

  • Zhou, J.; Neale, J.H.; Pomper, M.G.; Kozikowski, A.P.
    NAAG peptidase inhibitors and their potential for diagnosis and therapy (2005), Nat. Rev. Drug Discov., 4, 1015-1026.
    View publication on PubMed
Search for more literature for 3.4.17.21

Application

Application Comment Organism
diagnostics the enzyme, prostate-specific membrane antigen, is a good marker for prostate cancer Homo sapiens
pharmacology enzyme inhibitors are used in therapy of neruological disorders, overview Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
prostate-specific membrane antigen crystal structure analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid i.e. inhibitor ZJ17 Homo sapiens
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid i.e. inhibitor ZJ17 Rattus norvegicus
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid i.e. inhibitor ZJ38 Homo sapiens
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid i.e. inhibitor ZJ38 Rattus norvegicus
(S)-2-[3-((S)-1-carboxy-3-(methylsulfanyl)propyl)ureido]pentanedioic acid i.e. inhibitor ZJ11 Homo sapiens
(S)-2-[3-((S)-1-carboxy-3-(methylsulfanyl)propyl)ureido]pentanedioic acid i.e. inhibitor ZJ11 Rattus norvegicus
(S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid i.e. inhibitor ZJ43 Homo sapiens
(S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid i.e. inhibitor ZJ43 Rattus norvegicus
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid
-
 Homo sapiens
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid
-
 Rattus norvegicus
2-(3-mercaptopropyl)-pentanedioic acid i.e. 2-MPPA or GPI5693 Homo sapiens
2-(3-mercaptopropyl)-pentanedioic acid i.e. 2-MPPA or GPI5693 Rattus norvegicus
2-(phosphonomethyl)-pentanedioic acid i.e. 2-PMPA Homo sapiens
2-(phosphonomethyl)-pentanedioic acid i.e. 2-PMPA Rattus norvegicus
4,4'-phosphinicobis(butane-1,3-dicarboxylic acid) i.e. PBDA, effects of stereoisomers, overview Homo sapiens
4,4'-phosphinicobis(butane-1,3-dicarboxylic acid) i.e. PBDA Rattus norvegicus
diazabicycloalkane cis- and trans-isomers, dipeptide mimetic Homo sapiens
diazabicycloalkane cis- and trans-isomers, dipeptide mimetic Rattus norvegicus
GPI5232 i.e. 2-([((hydroxypentyfluorophenyl)methyl)phosphinoyl]methyl)pentanedioic acid Homo sapiens
GPI5232 i.e. 2-([((hydroxypentyfluorophenyl)methyl)phosphinoyl]methyl)pentanedioic acid Rattus norvegicus
additional information design of urea-based NAAG peptidase-specific inhibitors, IC50 values of the stereoisomers, inhibition strategies, overview, inhibitors are used in therapy of neurological disorders, overview, construction of a human traumatic brain injury, TBI, to test inhibitor effects, overview Homo sapiens
additional information design of urea-based NAAG peptidase-specific inhibitors, inhibition strategies, overview, construction of a stroke rat model and traumatic brain injury, TBI, to test inhibitor effects, overview Rattus norvegicus
VA-033 i.e. 2-([(benzyloxy)phosphonyl]methyl)pentanedioic acid Homo sapiens
VA-033 i.e. 2-([(benzyloxy)phosphonyl]methyl)pentanedioic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type II membrane glycoprotein Homo sapiens 16020
-
membrane type II membrane glycoprotein Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-metallopeptidase Homo sapiens
Zn2+ zinc-metallopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Rattus norvegicus supply of the primary excitatory neurotransmitter glutamate N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Homo sapiens supply of the primary excitatory neurotransmitter glutamate, the enzyme is involved in neurological disorders, and neuropathic and inflammatory pain N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein type II membrane glycoprotein Homo sapiens
glycoprotein type II membrane glycoprotein Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
central nervous system
-
 Homo sapiens
-
central nervous system
-
 Rattus norvegicus
-
glial cell
-
 Homo sapiens
-
hippocampus
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
neuron
-
 Rattus norvegicus
-
peripheral nervous system
-
 Homo sapiens
-
peripheral nervous system
-
 Rattus norvegicus
-
prostate cancer cell prostate-specific membrane antigen, PSMA Homo sapiens
-
prostate gland prostate-specific membrane antigen, PSMA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O supply of the primary excitatory neurotransmitter glutamate Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O supply of the primary excitatory neurotransmitter glutamate, the enzyme is involved in neurological disorders, and neuropathic and inflammatory pain Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
GCPII
-
 Homo sapiens
GCPII
-
 Rattus norvegicus
GCPIII
-
 Homo sapiens
GCPIII
-
 Rattus norvegicus
NAAG peptidase
-
 Homo sapiens
NAAG peptidase
-
 Rattus norvegicus
Prostate-specific membrane antigen
-
 Homo sapiens
PSMA
-
 Homo sapiens