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Literature summary for 3.4.17.21 extracted from

  • Christiansen, J.J.; Rajasekaran, S.A.; Inge, L.; Cheng, L.; Anilkumar, G.; Bander, N.H.; Rajasekaran, A.K.
    N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy (2005), Mol. Cancer Ther., 4, 704-714.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
stable expression in MDCK cells of truncated PMSA-DELTA103-750 as GFP-fusion protein and of the extracellular domain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information Vinca alkaloids destabilize the microtubules leading to basolateral expression of the enzyme and its integration into the basolateral membrane Homo sapiens
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plasma membrane direct targeting of the enzyme to the apical plasma membrane, correct sorting into appropriate post-Golgi vesicles depends on the N-glycosylation of the enzyme, integrity of the microtubule skeleton is required for enzyme localization in the apical plasma membrane Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation, correct sorting into appropriate post-Golgi vesicles for targeting into the apical plasma membrane depends on the N-glycosylation of the enzyme, inhibition of N-glycosylation abolishes the polarized enzyme expression, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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Homo sapiens
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LNCaP cell originating from a prostate cancer lymph node metastasis Homo sapiens
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prostate epithelial cells Homo sapiens
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prostate cancer cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
?

Subunits

Subunits Comment Organism
More the enzyme posseses an extracellular domain, a transmembrane segment, and a cytoplasmic tail Homo sapiens

Synonyms

Synonyms Comment Organism
PMSA
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Homo sapiens
Prostate-specific membrane antigen
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Homo sapiens