Cloned (Comment) | Organism |
---|---|
stable expression in MDCK cells of truncated PMSA-DELTA103-750 as GFP-fusion protein and of the extracellular domain | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | Vinca alkaloids destabilize the microtubules leading to basolateral expression of the enzyme and its integration into the basolateral membrane | Homo sapiens | - |
- |
plasma membrane | direct targeting of the enzyme to the apical plasma membrane, correct sorting into appropriate post-Golgi vesicles depends on the N-glycosylation of the enzyme, integrity of the microtubule skeleton is required for enzyme localization in the apical plasma membrane | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation, correct sorting into appropriate post-Golgi vesicles for targeting into the apical plasma membrane depends on the N-glycosylation of the enzyme, inhibition of N-glycosylation abolishes the polarized enzyme expression, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
LNCaP cell | originating from a prostate cancer lymph node metastasis | Homo sapiens | - |
prostate | epithelial cells | Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme posseses an extracellular domain, a transmembrane segment, and a cytoplasmic tail | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PMSA | - |
Homo sapiens |
Prostate-specific membrane antigen | - |
Homo sapiens |