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Literature summary for 3.4.17.21 extracted from

  • Sanabria, E.R.; Wozniak, K.M.; Slusher, B.S.; Keller, A.
    GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism (2004), J. Neurophysiol., 91, 182-193.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.21

Inhibitors

Inhibitors Comment Organism Structure
3-(3-mercaptopropyl)pentanedioic acid presynaptic action of enzyme inhibition, enzyme inhibition depresses mossy fiber-CA3 synaptic transmission Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
synapse fiber C3 Rattus norvegicus 45202
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme inhibition depresses mossy fiber-CA3 synaptic transmission ?
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Rattus norvegicus i.e. NAAG, a presynaptically active endogenous neuropeptide which is cleaved by the enzyme in the extracellular space N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuron CA3 pyramidal neuron Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme inhibition depresses mossy fiber-CA3 synaptic transmission Rattus norvegicus ?
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O
-
 Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG, a presynaptically active endogenous neuropeptide which is cleaved by the enzyme in the extracellular space Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
GCP II
-
 Rattus norvegicus
N-Acetylated alpha-linked acidic dipeptidase
-
 Rattus norvegicus
NAALADase
-
 Rattus norvegicus