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Literature summary for 3.4.17.21 extracted from

  • Urazaev, A.K.; Grossfeld, R.M.; Lieberman, E.M.
    Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors (2005), J. Neurochem., 93, 605-610.
    View publication on PubMed
Search for more literature for 3.4.17.21

Inhibitors

Inhibitors Comment Organism Structure
(S)-alpha-ethylglutamate specific group II metabotropic glutamate receptor antagonist, in vivo activity Procambarus clarkii
2-(phosphonomethyl)-pentanedioic acid 2-PMPA, specific GCPII inhibitor, in vivo activity Procambarus clarkii
additional information glutamate receptor antagonists reduce the enzyme activity in vivo, overview Procambarus clarkii

Metals/Ions

Metals/Ions Comment Organism Structure
K+ extracellularly applied K+ increases the enzyme activity in vivo in glial cells and the ventral nerve cord Procambarus clarkii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Procambarus clarkii enzyme regulation is mediated by glial glutamate and acetylcholine receptors in the nervous tissue N-acetyl-alpha-L-aspartate + L-glutamate
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Organism

Organism UniProt Comment Textmining
Procambarus clarkii
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Source Tissue

Source Tissue Comment Organism Textmining
nerve
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 Procambarus clarkii
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ventral nerve cord
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 Procambarus clarkii
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O enzyme regulation is mediated by glial glutamate and acetylcholine receptors in the nervous tissue Procambarus clarkii N-acetyl-alpha-L-aspartate + L-glutamate
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 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Procambarus clarkii N-acetyl-alpha-L-aspartate + L-glutamate
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 ?

Synonyms

Synonyms Comment Organism
GCPII
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 Procambarus clarkii