Cloned (Comment) | Organism |
---|---|
gene FOLH1, DNA sequence variants analysis, expression regulation by PMSA enhancer, PSME, involving Ca2+, overview, localization on chromosome 11p11-12, another highly homologous gene is located at 11q14.3 and is expressed in several tissues, e.g. kidney and liver, but not in prostate | Homo sapiens |
gene PMSA, DNA sequence variants analysis, expression regulation by PMSA enhancer, PSME, involving Ca2+, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the androgen receptor negatively regulates the enzyme expression | Homo sapiens | |
additional information | the androgen receptor negatively regulates the enzyme expression | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Rattus norvegicus | 5886 | - |
plasma membrane | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Mus musculus | 5886 | - |
plasma membrane | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Homo sapiens | 5886 | - |
synapse | neuronal | Mus musculus | 45202 | - |
synapse | neuronal | Homo sapiens | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | positively regulates enzyme expression | Mus musculus | |
Ca2+ | positively regulates enzyme expression | Homo sapiens | |
Zn2+ | involved in substrate binding | Mus musculus | |
Zn2+ | involved in substrate binding | Homo sapiens | |
Zn2+ | involved in substrate binding | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | ? | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells and involvement in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Mus musculus | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Rattus norvegicus | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
poly-gamma-glutamate folate + H2O | Mus musculus | activity outside of the cell | ? | - |
? | |
poly-gamma-glutamate folate + H2O | Homo sapiens | activity outside of the cell | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
bifunctional enzyme, gene PMSA | - |
Mus musculus | - |
bifunctional enzyme, gene folh1 | - |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the enzyme is a type II membrane glycoprotein | Mus musculus |
glycoprotein | the enzyme is a type II membrane glycoprotein | Homo sapiens |
glycoprotein | the enzyme is a type II membrane glycoprotein | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate carcinoma cell | - |
Mus musculus | - |
prostate carcinoma cell | - |
Homo sapiens | - |
prostate gland | - |
Mus musculus | - |
prostate gland | - |
Homo sapiens | - |
prostate gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | Homo sapiens | ? | - |
? | |
additional information | bifunctional enzyme performing folate hydrolase and N-acetylated alpha-linked acidic dipeptidase, NAALADase, activities | Mus musculus | ? | - |
? | |
additional information | bifunctional enzyme performing folate hydrolase and N-acetylated alpha-linked acidic dipeptidase, NAALADase, activities | Homo sapiens | ? | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Mus musculus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells and involvement in prostate cancer and metastasis, overview | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | Mus musculus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
poly-gamma-glutamate folate + H2O | - |
Mus musculus | ? | - |
? | |
poly-gamma-glutamate folate + H2O | - |
Homo sapiens | ? | - |
? | |
poly-gamma-glutamate folate + H2O | activity outside of the cell | Mus musculus | ? | - |
? | |
poly-gamma-glutamate folate + H2O | activity outside of the cell | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme is a is monomeric or dimeric type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Mus musculus |
More | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Rattus norvegicus |
More | the enzyme is monomeric or dimeric a type II membrane glycoprotein with an intracellular segment of amino acid residues 1-18, a transmembrane domain of residues 19-43, and an extensive extracellular domain comprising residues 44-750 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FOLH1 | - |
Mus musculus |
FOLH1 | - |
Homo sapiens |
N-Acetylated alpha-linked acidic dipeptidase | - |
Mus musculus |
N-Acetylated alpha-linked acidic dipeptidase | - |
Homo sapiens |
N-Acetylated alpha-linked acidic dipeptidase | - |
Rattus norvegicus |
NAALADase | - |
Mus musculus |
NAALADase | - |
Homo sapiens |
NAALADase | - |
Rattus norvegicus |
prostate specific membrane antigen | - |
Mus musculus |
prostate specific membrane antigen | - |
Homo sapiens |
PSMA | - |
Mus musculus |
PSMA | - |
Homo sapiens |