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Literature summary for 3.4.17.21 extracted from

  • Long, J.B.; Yourick, D.L.; Slusher, B.S.; Robinson, M.B.; Meyerhoff, J.L.
    Inhibition of glutamate carboxypeptidase II (NAALADase) protects against dynorphin A-induced ischemic spinal cord injury in rats (2005), Eur. J. Pharmacol., 508, 115-122.
    View publication on PubMed
Search for more literature for 3.4.17.21

Activating Compound

Activating Compound Comment Organism Structure
dynorphin A activates glutamate production in the spinal cord Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(phosphonomethyl)-pentanedioic acid i.e. 2-PMPA, enzyme inhibition protects the rats in vivo against ischemic injury to the brain and spinal cord, and hypoxic and metabolic injury to neuronal cells in culture Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Rattus norvegicus
-
 N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Rattus norvegicus
-
spinal cord
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O
-
 Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Rattus norvegicus N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
GCP II
-
 Rattus norvegicus
N-acetyl-alpha-linked acidic dipeptidase
-
 Rattus norvegicus
NAALADase
-
 Rattus norvegicus