Literature summary for 3.4.17.21 extracted from

Yamamoto, T.; Hirasawa, S.; Wroblewska, B.; Grajkowska, E.; Zhou, J.; Kozikowski, A.; Wroblewski, J.; Neale, J.H.
Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model (2004), Eur. J. Neurosci., 20, 483-494.

Search for more literature for 3.4.17.21

Inhibitors

Inhibitors	Comment	Organism	Structure
N-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ17, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, overview	Homo sapiens
N-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ17, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, agonist and antagonist activity on recombinantly expressed metabotropic glutamate receptor, overview	Rattus norvegicus
N-[[(1S)-1-carboxy-3-(methylsulfanyl)propyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ11, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, overview	Homo sapiens
N-[[(1S)-1-carboxy-3-(methylsulfanyl)propyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ11, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, agonist and antagonist activity on recombinantly expressed metabotropic glutamate receptor, overview	Rattus norvegicus
N-[[(1S)-1-carboxy-3-methylbutyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ43, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, overview	Homo sapiens
N-[[(1S)-1-carboxy-3-methylbutyl]carbamoyl]-L-glutamic acid	i.e. inhibitor ZJ43, antinociceptive effect of the inhibitor in the rat formalin test and the rat neuropathic pain model, agonist and antagonist activity on recombinantly expressed metabotropic glutamate receptor, overview	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-
membrane	-	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	Homo sapiens	-	N-acetyl-alpha-L-aspartate + L-glutamate	-	?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	Rattus norvegicus	-	N-acetyl-alpha-L-aspartate + L-glutamate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially by membrane preparation	Homo sapiens
partially by membrane preparation	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Homo sapiens	-
cell culture	-	Rattus norvegicus	-
neuron	-	Homo sapiens	-
neuron	-	Rattus norvegicus	-
sciatic nerve	modeling	Homo sapiens	-
sciatic nerve	modeling	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	-	Homo sapiens	N-acetyl-alpha-L-aspartate + L-glutamate	-	?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	-	Rattus norvegicus	N-acetyl-alpha-L-aspartate + L-glutamate	-	?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	i.e. NAAG	Homo sapiens	N-acetyl-alpha-L-aspartate + L-glutamate	-	?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	i.e. NAAG	Rattus norvegicus	N-acetyl-alpha-L-aspartate + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
GCPII	-	Homo sapiens
GCPII	-	Rattus norvegicus
GPCPII	-	Homo sapiens
GPCPII	-	Rattus norvegicus
N-acetylaspartylglutamate peptidase	-	Homo sapiens
N-acetylaspartylglutamate peptidase	-	Rattus norvegicus
NAAG peptidase	-	Homo sapiens
NAAG peptidase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens
7.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)