Literature summary for 3.4.17.12 extracted from

Skidgel, R.A.; Stanisavljevic, S.; Erdoes, E.G.
Kinin- and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells (2006), Biol. Chem., 387, 159-165.

Search for more literature for 3.4.17.12

Activating Compound

Activating Compound	Comment	Organism	Structure
IFN-gamma	CPM activity can be upregulated approximately two-fold in HLMVECs by IL-1beta plus IFN-gamma treatment	Homo sapiens
IL-1beta	CPM activity can be upregulated approximately two-fold in HLMVECs by IL-1beta plus IFN-gamma treatment, IL-1beta alone can upregulate CPM expression	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
DL-2-mercaptomethyl-3-guanidino-ethylthiopropanoic acid	-	Bos taurus
DL-2-mercaptomethyl-3-guanidino-ethylthiopropanoic acid	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-
plasma membrane	-	Bos taurus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	glycosylphosphatidylinositol-anchored protein	Homo sapiens
glycoprotein	glycosylphosphatidylinositol-anchored protein	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Homo sapiens	-
endothelial cell	-	Bos taurus	-
human lung microvascular endothelial cell	HLMVEC	Homo sapiens	-
lung	-	Homo sapiens	-
lung	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	bradykinin	Homo sapiens	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine	-	?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	bradykinin	Bos taurus	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine	-	?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	kallidin	Homo sapiens	Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine	-	?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	kallidin	Bos taurus	Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine	-	?

Synonyms

Synonyms	Comment	Organism
carboxypeptidase M	-	Homo sapiens
carboxypeptidase M	-	Bos taurus

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Release 2023.1 (January 2023)