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Literature summary for 3.4.17.10 extracted from

  • Fricker, L.D.
    Carboxypeptidase E (1988), Annu. Rev. Physiol., 50, 309-321.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Bos taurus
1,10-phenanthroline
-
Rattus norvegicus
Aminopropylmercapto succinic acid
-
Bos taurus
Aminopropylmercapto succinic acid
-
Rattus norvegicus
Guanidinoethylmercaptosuccinic acid
-
Bos taurus
Guanidinoethylmercaptosuccinic acid
-
Rattus norvegicus
p-chloromercuriphenyl sulfonate
-
Bos taurus
p-chloromercuriphenyl sulfonate
-
Rattus norvegicus
sulfhydryl reagents
-
Bos taurus
sulfhydryl reagents
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-
membrane
-
Bos taurus 16020
-
secretory granule
-
Rattus norvegicus 30141
-
secretory granule chromaffin granules Bos taurus 30141
-
soluble
-
Rattus norvegicus
-
-
soluble
-
Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activates Rattus norvegicus
Co2+ activates Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids ?
-
?
additional information Bos taurus highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids ?
-
?
additional information Rattus norvegicus releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones ?
-
?
additional information Bos taurus releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Rattus norvegicus
side-chain modification glycoprotein Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
Rattus norvegicus
-
adrenal medulla
-
Bos taurus
-
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-
heart low activity Rattus norvegicus
-
heart low activity Bos taurus
-
hypophysis
-
Rattus norvegicus
-
hypophysis
-
Bos taurus
-
additional information 2 forms: soluble and membrane-bound are present in most tissues Rattus norvegicus
-
additional information 2 forms: soluble and membrane-bound are present in most tissues Bos taurus
-
pancreas low activity Rattus norvegicus
-
pancreas low activity Bos taurus
-
spleen low activity Rattus norvegicus
-
spleen low activity Bos taurus
-
testis low activity Rattus norvegicus
-
testis low activity Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Met)enkephalin-Arg + H2O
-
Rattus norvegicus Tyr-Gly-Gly-Phe-Met + Arg
-
?
(Met)enkephalin-Arg + H2O
-
Bos taurus Tyr-Gly-Gly-Phe-Met + Arg
-
?
(Met)enkephalin-Lys + H2O
-
Rattus norvegicus Tyr-Gly-Gly-Phe-Met + Lys
-
?
(Met)enkephalin-Lys + H2O
-
Bos taurus Tyr-Gly-Gly-Phe-Met + Lys
-
?
additional information highly specific for C-terminal basic amino acids in decreasing order: Arg, Lys,His, does not cleave other amino acids Rattus norvegicus ?
-
?
additional information highly specific for C-terminal basic amino acids in decreasing order: Arg, Lys,His, does not cleave other amino acids Bos taurus ?
-
?
additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin Rattus norvegicus ?
-
?
additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin Bos taurus ?
-
?
additional information highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids Rattus norvegicus ?
-
?
additional information highly specific for C-terminal basic amino acids Arg in decreasing order: Arg, Lys, His, does not cleave other amino acids Bos taurus ?
-
?
additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones Rattus norvegicus ?
-
?
additional information releases C-terminal arginine or lysine residues from the hexapeptide precursor of [Met]enkephalin and [Leu]enkephalin, forming the pentapeptide enkephalin, associated with the biosynthesis of many peptide neurotransmitters and hormones Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
Rattus norvegicus
5 6
-
Bos taurus