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Literature summary for 3.4.17.1 extracted from

  • Pejler, G.; Aabrink, M.; Ringvall, M.; Wernersson, S.
    Mast cell proteases (2007), Adv. Immunol., 95, 167-255.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
proteoglycan there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan Mus musculus
proteoglycan there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan Homo sapiens
proteoglycan there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan Rattus norvegicus

Application

Application Comment Organism
medicine mast cell-proteases are considered as promising drug targets Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
latexin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
Mus musculus 30141
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme Mus musculus
proteolytic modification cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme Homo sapiens
proteolytic modification cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestinal mucosa
-
Mus musculus
-
intestinal mucosa
-
Homo sapiens
-
mast cell
-
Mus musculus
-
mast cell
-
Homo sapiens
-
mast cell
-
Rattus norvegicus
-
peritoneum
-
Mus musculus
-
secretion
-
Homo sapiens
-
skin
-
Mus musculus
-
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O shown in an ex vivo system of peritoneal exudates cells Mus musculus angiotensin II + His-Leu
-
?
angiotensin I + H2O shown in an ex vivo system of peritoneal exudates cells Homo sapiens angiotensin II + His-Leu
-
?
angiotensin I + H2O shown in an ex vivo system of peritoneal exudates cells Rattus norvegicus angiotensin II + His-Leu
-
?
angiotensin I + H2O
-
Mus musculus des-Leu10 angiotensin I + Leu
-
?
angiotensin I + H2O
-
Homo sapiens des-Leu10 angiotensin I + Leu
-
?
angiotensin I + H2O
-
Rattus norvegicus des-Leu10 angiotensin I + Leu
-
?
apoB-100 + H2O
-
Mus musculus ?
-
?
apoB-100 + H2O
-
Homo sapiens ?
-
?
apoB-100 + H2O
-
Rattus norvegicus ?
-
?
ET-1 + H2O
-
Mus musculus ?
-
?
ET-1 + H2O
-
Homo sapiens ?
-
?
ET-1 + H2O
-
Rattus norvegicus ?
-
?
Leu5-enkephalin + H2O
-
Mus musculus ?
-
?
Leu5-enkephalin + H2O
-
Homo sapiens ?
-
?
Leu5-enkephalin + H2O
-
Rattus norvegicus ?
-
?
neurotensin + H2O
-
Mus musculus ?
-
?
neurotensin + H2O
-
Homo sapiens ?
-
?
neurotensin + H2O
-
Rattus norvegicus ?
-
?
sarafotoxin + H2O
-
Mus musculus ?
-
?
sarafotoxin + H2O
-
Homo sapiens ?
-
?
sarafotoxin + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
carboxypeptidase a
-
Mus musculus
carboxypeptidase a
-
Homo sapiens
carboxypeptidase a
-
Rattus norvegicus
CPA
-
Mus musculus
CPA
-
Homo sapiens
CPA
-
Rattus norvegicus
MC-CPA
-
Mus musculus
MC-CPA
-
Homo sapiens
MC-CPA
-
Rattus norvegicus