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Literature summary for 3.4.17.1 extracted from
- Mast cell proteases (2007), Adv. Immunol., 95, 167-255.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| proteoglycan | there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan | Homo sapiens | |
| proteoglycan | there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan | Mus musculus | |
| proteoglycan | there is evidence indicating that the processing of pro-MC-CPA into active protease is dependent on proteoglycan | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | mast cell-proteases are considered as promising drug targets | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| latexin | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| secretory granule | - |
Mus musculus | 30141 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme | Homo sapiens |
| proteolytic modification | cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme | Mus musculus |
| proteolytic modification | cleavage of the signal peptide and subsequent cleavage of the propeptide results in the formation of the mature enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestinal mucosa | - |
Homo sapiens | - |
| intestinal mucosa | - |
Mus musculus | - |
| mast cell | - |
Homo sapiens | - |
| mast cell | - |
Mus musculus | - |
| mast cell | - |
Rattus norvegicus | - |
| peritoneum | - |
Mus musculus | - |
| secretion | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| skin | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | shown in an ex vivo system of peritoneal exudates cells | Homo sapiens | angiotensin II + His-Leu | - |
? |  |
| angiotensin I + H2O | shown in an ex vivo system of peritoneal exudates cells | Mus musculus | angiotensin II + His-Leu | - |
? | |
| angiotensin I + H2O | shown in an ex vivo system of peritoneal exudates cells | Rattus norvegicus | angiotensin II + His-Leu | - |
? | |
| angiotensin I + H2O | - |
Homo sapiens | des-Leu10 angiotensin I + Leu | - |
? | |
| angiotensin I + H2O | - |
Mus musculus | des-Leu10 angiotensin I + Leu | - |
? | |
| angiotensin I + H2O | - |
Rattus norvegicus | des-Leu10 angiotensin I + Leu | - |
? | |
| apoB-100 + H2O | - |
Homo sapiens | ? | - |
? | |
| apoB-100 + H2O | - |
Mus musculus | ? | - |
? | |
| apoB-100 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| ET-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| ET-1 + H2O | - |
Mus musculus | ? | - |
? | |
| ET-1 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Leu5-enkephalin + H2O | - |
Homo sapiens | ? | - |
? | |
| Leu5-enkephalin + H2O | - |
Mus musculus | ? | - |
? | |
| Leu5-enkephalin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
| neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| sarafotoxin + H2O | - |
Homo sapiens | ? | - |
? | |
| sarafotoxin + H2O | - |
Mus musculus | ? | - |
? | |
| sarafotoxin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxypeptidase a | - |
Homo sapiens |
| carboxypeptidase a | - |
Mus musculus |
| carboxypeptidase a | - |
Rattus norvegicus |
| CPA | - |
Homo sapiens |
| CPA | - |
Mus musculus |
| CPA | - |
Rattus norvegicus |
| MC-CPA | - |
Homo sapiens |
| MC-CPA | - |
Mus musculus |
| MC-CPA | - |
Rattus norvegicus |
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