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Literature summary for 3.4.17.1 extracted from

  • Park, J.D.; Kim, D.H.
    Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A (2004), Bioorg. Med. Chem., 12, 2349-2356.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R)-N-(N-hydroxysulfamoyl)phenylalanine competitive Bos taurus
(R)-N-(N-hydroxysulfamoyl)phenylalanine competitive Homo sapiens
(R)-N-formyl-N-hydroxyphenylalanine
-
Bos taurus
(R)-N-hydroxy-N-sulfamoyl-beta-phenylalanine competitive Bos taurus
(R)-N-hydroxy-N-sulfamoyl-beta-phenylalanine competitive Homo sapiens
(R)-N-sulfamoylphenylalanine
-
Bos taurus
(R)-N-sulfamoylphenylalanine competitive Homo sapiens
(R,S)-3-phenyl-2-sulfamoyloxypropionic acid competitive Homo sapiens
(R,S)-N-(hydroxyaminocarbonyl)-phenylalanine competitive Homo sapiens
(R,S)-N-(N-hydroxysulfamoyl)phenylalanine competitive Homo sapiens
(R,S)-N-sulfamoylphenylalanine competitive Homo sapiens
(RS)-2-benzyl-3-sulfamoylpropionic acid
-
Bos taurus
(RS)-3-phenyl-2-sulfamoyloxypropionic acid competitive Bos taurus
(RS)-N-(hydroxyaminocarbonyl)-phenylalanine
-
Bos taurus
(RS)-N-formyl-N-hydroxyphenylalanine
-
Bos taurus
(RS)-N-sulfamoylphenylalanine
-
Bos taurus
(S)-N-(N-hydroxysulfamoyl)phenylalanine competitive Bos taurus
(S)-N-(N-hydroxysulfamoyl)phenylalanine competitive Homo sapiens
(S)-N-formyl-N-hydroxyphenylalanine
-
Bos taurus
(S)-N-hydroxy-N-sulfamoyl-beta-phenylalanine competitive Bos taurus
(S)-N-hydroxy-N-sulfamoyl-beta-phenylalanine competitive Homo sapiens
(S)-N-sulfamoylphenylalanine
-
Bos taurus
(S)-N-sulfamoylphenylalanine competitive Homo sapiens
additional information sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A, synthesis, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ binds and stabilizes the active site Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-(trans-4-chlorocinnamoyl)-L-phenyllactic acid + H2O
-
Homo sapiens trans-4-chlorocinnamic acid + L-phenyllactic acid
-
?
O-(trans-p-chlorocinnamoyl)-L-phenylacetic acid + H2O
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
CPA
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00056
-
(R)-N-formyl-N-hydroxyphenylalanine pH 7.5 Bos taurus
0.00065
-
(S)-N-sulfamoylphenylalanine pH 7.5 Bos taurus
0.00142
-
(RS)-N-sulfamoylphenylalanine pH 7.5 Bos taurus
0.00198
-
(RS)-3-phenyl-2-sulfamoyloxypropionic acid pH 7.5 Bos taurus
0.00209
-
(RS)-N-(hydroxyaminocarbonyl)-phenylalanine pH 7.5 Bos taurus
0.00209
-
(R,S)-N-(hydroxyaminocarbonyl)-phenylalanine pH 7.5 Homo sapiens
0.0032
-
(S)-N-(N-hydroxysulfamoyl)phenylalanine pH 7.5 Homo sapiens
0.0032
-
(S)-N-(N-hydroxysulfamoyl)phenylalanine pH 7.5 Bos taurus
0.00353
-
(RS)-2-benzyl-3-sulfamoylpropionic acid pH 7.5 Bos taurus
0.00495
-
(S)-N-formyl-N-hydroxyphenylalanine pH 7.5 Bos taurus
0.039
-
(R)-N-hydroxy-N-sulfamoyl-beta-phenylalanine pH 7.5 Homo sapiens
0.039
-
(R)-N-hydroxy-N-sulfamoyl-beta-phenylalanine pH 7.5 Bos taurus
0.067
-
(RS)-N-formyl-N-hydroxyphenylalanine pH 7.5 Bos taurus
0.072
-
(R)-N-(N-hydroxysulfamoyl)phenylalanine pH 7.5 Homo sapiens
0.072
-
(R)-N-(N-hydroxysulfamoyl)phenylalanine pH 7.5 Bos taurus
0.47
-
(R)-N-sulfamoylphenylalanine pH 7.5 Bos taurus
1.9
-
(S)-N-hydroxy-N-sulfamoyl-beta-phenylalanine pH 7.5 Homo sapiens
1.9
-
(S)-N-hydroxy-N-sulfamoyl-beta-phenylalanine pH 7.5 Bos taurus