Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | G3HR95 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
Synonyms | Comment | Organism |
---|---|---|
CPD | - |
Cricetulus griseus |
General Information | Comment | Organism |
---|---|---|
physiological function | CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells. Knockdown of CpD by RNAi increases C-terminal lysine levels of antibodies, whereas there is no obvious change in C-terminal lysine levels when carboxypeptidase CpM, CpN, CpB, or CpE is knocked downIn a CpD knockout mutant, C-terminal lysine cleavage is completely abolished | Cricetulus griseus |