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Literature summary for 3.4.16.6 extracted from

  • O'Malley, P.G.; Sangster, S.M.; Abdelmagid, S.A.; Bearne, S.L.; Too, C.K.
    Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells (2005), Biochem. J., 390, 665-673.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline noncompetitive Homo sapiens
1,10-phenanthroline noncompetitive Rattus norvegicus
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid competitive Homo sapiens
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.063
-
dansyl-L-Ala-L-Arg pH 5.6, 37°C Homo sapiens
0.132
-
dansyl-L-Ala-L-Arg pH 5.6, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus mainly trans-Golgi network Homo sapiens 5794
-
nucleus 98% of enzymic activity Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
cytokine-inducible isoform CPD-N with incomplete N-terminal domain and intact domains II and III
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell exclusive expression of 180 kDa isoform Homo sapiens
-
Nb2 cell T-lymphoma cell, exclusive synthesis of isoform SPD-N Rattus norvegicus
-
Nb2-Sp cell lymphoma cell, exclusive synthesis of isoform SPD-N Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dansyl-L-Ala-L-Arg + H2O
-
Homo sapiens dansyl-L-Ala + L-Arg
-
?
dansyl-L-Ala-L-Arg + H2O
-
Rattus norvegicus dansyl-L-Ala + L-Arg
-
?

Subunits

Subunits Comment Organism
More enzyme co-immunoprecipitates with protein phosphatase 2A and alpha4 phosphoprotein Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6
-
-
Rattus norvegicus
5.6
-
and 6.5-7.0. Activity maximum at pH 5.6 is due to activity of domain II, at pH 6.5-7.0 due to domain I Homo sapiens
6.5 7 and 5.6. Activity maximum at pH 5.6 is due to activity of domain II, at pH 6.5-7.0 due to domain I Homo sapiens