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Literature summary for 3.4.16.5 extracted from

  • Bayes, A.; Fernandez, D.; Sola, M.; Marrero, A.; Garcia-Pique, S.; Aviles, F.X.; Vendrell, J.; Gomis-Rueth, F.X.
    Caught after the act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide (2007), Biochemistry, 46, 6921-6930.
    View publication on PubMed
Search for more literature for 3.4.16.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapour diffusion method with 0.2 M potassium thiocyanate and 20% PEG 3350 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Phe-Asn-Arg-Ala-Val-Asp
-
 Homo sapiens
Phe-Asn-Arg-Ala-Val-Val
-
 Homo sapiens
Phe-Asn-Arg-Pro-Val-Asp
-
 Homo sapiens
Phe-Asn-Arg-Pro-Val-Val
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
TSK-DEAE 5PW column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-methoxyphenyl-azoformyl)-L-Phe-OH + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
A-type metallocarboxypeptidase
-
 Homo sapiens
carboxypeptidase A4
-
 Homo sapiens
CPA4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.63
-
 in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5) Homo sapiens Phe-Asn-Arg-Ala-Val-Val
0.71
-
 in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5) Homo sapiens Phe-Asn-Arg-Pro-Val-Val
0.72
-
 in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5) Homo sapiens Phe-Asn-Arg-Ala-Val-Asp
0.91
-
 in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5) Homo sapiens Phe-Asn-Arg-Pro-Val-Asp