Literature summary for 3.4.16.5 extracted from

Satoh, Y.; Kadota, Y.; Oheda, Y.; Kuwahara, J.; Aikawa, S.; Matsuzawa, F.; Doi, H.; Aoyagi, T.; Sakuraba, H.; Itoh, K.
Microbial serine carboxypeptidase inhibitors. Comparative analysis of actions on homologous enzymes derived from man, yeast and wheat. [Erratum to document cited in CA142:109255] (2004), J. Antibiot., 57, 316-325.

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Inhibitors

Inhibitors	Comment	Organism	Structure
chymostatin	IC50 at pH 5.6: 0.092 mM, IC50 at pH 6.5: above 0.1 mM	Homo sapiens
chymostatin	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Saccharomyces cerevisiae
chymostatin	IC50 at pH 5.6: 0.013 mM, IC50 at pH 6.5: 0.0022 mM	Triticum aestivum
ebelactone B	IC50 at pH 5.6: 0.0016 mM, IC50 at pH 6.5: 0.002 mM	Homo sapiens
ebelactone B	IC50 at pH 5.6: 0.00002 mM, IC50 at pH 6.5: 0.00003 mM	Saccharomyces cerevisiae
ebelactone B	IC50: 0.0021 mM (at pH 5.6), IC50: 0.0015 mM (at pH 6.5)	Triticum aestivum
lactacystin	IC50 at pH 5.6: 0.0052 mM, IC50 at pH 6.5: 0.0018 mM	Homo sapiens
lactacystin	IC50 at pH 5.6: 0.048 mM, IC50 at pH 6.5: 0.031 mM	Saccharomyces cerevisiae
lactacystin	IC50 at pH 5.6: 0.0014 mM, IC50 at pH 6.5: 0.0043 mM	Triticum aestivum
omuralide	IC50 at pH 5.6: 0.000099 mM, IC50 at pH 6.5: 0.000012 mM	Homo sapiens
omuralide	IC50 at pH 5.6: 0.000096 mM, IC50 at pH 6.5: 0.000078 mM	Saccharomyces cerevisiae
omuralide	IC50 at pH 5.6: 0.0000048 mM, IC50 at pH 6.5: 0.000002 mM	Triticum aestivum
piperastatin A	IC50 at pH 5.6: 0.018 mM, IC50 at pH 6.5: 0.032 mM	Homo sapiens
piperastatin A	IC50 at pH 5.6: 0.0041 mM, IC50 at pH 6.5: 0.0045 mM	Saccharomyces cerevisiae
piperastatin A	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Triticum aestivum
poststatin	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Homo sapiens
poststatin	IC50 at pH 5.6: 0.089 mM, IC50 at pH 6.5: 0.029 mM	Saccharomyces cerevisiae
poststatin	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Triticum aestivum

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Saccharomyces cerevisiae	-	-	-
Triticum aestivum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Leu + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe + Leu	-	?
benzyloxycarbonyl-Phe-Leu + H2O	-	Saccharomyces cerevisiae	benzyloxycarbonyl-Phe + Leu	-	?
benzyloxycarbonyl-Phe-Leu + H2O	-	Triticum aestivum	benzyloxycarbonyl-Phe + Leu	-	?

Synonyms

Synonyms	Comment	Organism
Carboxypeptidase II	-	Triticum aestivum
carboxypeptidase Y	-	Saccharomyces cerevisiae
cathepsin A	-	Homo sapiens
CPW	-	Triticum aestivum
hCath A	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000002	0.0000048	IC50 at pH 5.6: mM, IC50 at pH 6.5: 0.000002 mM	Triticum aestivum	omuralide
0.000012	0.000099	IC50 at pH 5.6: 0.000099 mM, IC50 at pH 6.5: 0.000012 mM	Homo sapiens	omuralide
0.00002	0.00003	IC50 at pH 5.6: 0.00002 mM, IC50 at pH 6.5: 0.00003 mM	Saccharomyces cerevisiae	ebelactone B
0.000078	0.000096	IC50 at pH 5.6: 0.000096 mM, IC50 at pH 6.5: 0.000078 mM	Saccharomyces cerevisiae	omuralide
0.0014	0.0043	IC50 at pH 5.6: 0.0014 mM, IC50 at pH 6.5: 0.0043 mM	Triticum aestivum	lactacystin
0.0015	-	IC50: 0.0021 mM (at pH 5.6), IC50: 0.0015 mM (at pH 6.5)	Triticum aestivum	ebelactone B
0.0016	0.002	IC50 at pH 5.6: 0.0016 mM, IC50 at pH 6.5: 0.002 mM	Homo sapiens	ebelactone B
0.0018	0.0052	IC50 at pH 5.6: 0.0052 mM, IC50 at pH 6.5: 0.0018 mM	Homo sapiens	lactacystin
0.0022	0.013	IC50 at pH 5.6: 0.013 mM, IC50 at pH 6.5: 0.0022 mM	Triticum aestivum	chymostatin
0.0041	0.0045	IC50 at pH 5.6: 0.0041 mM, IC50 at pH 6.5: 0.0045 mM	Saccharomyces cerevisiae	piperastatin A
0.018	0.032	IC50 at pH 5.6: 0.018 mM, IC50 at pH 6.5: 0.032 mM	Homo sapiens	piperastatin A
0.029	0.089	IC50 at pH 5.6:0.089 mM, IC50 at pH 6.5: 0.029 mM	Saccharomyces cerevisiae	poststatin
0.031	0.048	IC50 at pH 5.6: 0.048 mM, IC50 at pH 6.5: 0.031 mM	Saccharomyces cerevisiae	lactacystin
0.092	0.1	IC50 at pH 5.6: 0.092 mM, IC50 at pH 6.5: above 0.1 mM	Homo sapiens	chymostatin
0.1	-	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Saccharomyces cerevisiae	chymostatin
0.1	-	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Triticum aestivum	piperastatin A
0.1	-	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Homo sapiens	poststatin
0.1	-	IC50 at pH 5.6 and at pH 6.5: above 0.1 mM	Triticum aestivum	poststatin

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Release 2023.1 (January 2023)