Cloned (Comment) | Organism |
---|---|
- |
Actinomadura sp. |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor (2R)-2-amino-7-oxo-7-[(4,4,4-trifluoro-3-oxobutan-2-yl)amino]heptanoic acid. The inhibitor is covalently bonded to the active serine Ser49, the carbonyl carbon is now tetrahedral, and the ketone oxygen occupies the oxyanion hole, defined by the backbone NH groups of Ser49 and Thr413. The D-methyl group is directed into a hydrophobic pocket comprised residues Gly148, Leu 349 and Met414. Branching from the tetrahedral carbon bonded to Ser49Ogamma, the CF3 group occupies the likely position of a leaving group in the tetrahedral intermediate of a peptidase substrate | Actinomadura sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-amino-7-oxo-7-[(4,4,4-trifluoro-3-oxobutan-2-yl)amino]heptanoic acid | i.e. D-alpha-aminopimelyl-(1,1,1-trifluoro-3-amino)butan-2-one | Actinomadura sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Actinomadura sp. | P39045 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Dac | - |
Actinomadura sp. |
DD-peptidase | - |
Actinomadura sp. |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00037 | - |
(2R)-2-amino-7-oxo-7-[(4,4,4-trifluoro-3-oxobutan-2-yl)amino]heptanoic acid | pH not specified in the publication, temperature not specified in the publication | Actinomadura sp. |