Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion, crystal structure of the phosphonal enzyme. The 1.1 A resolution structure of the enzyme in complex with phenyl glycyl-L-alpha-aminopimelyl-epsilon-(D-2-aminoethyl)phosphonate shows that the inhibitor is phosphorylated by the catalytic Ser62 | Streptomyces sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phenyl glycyl-L-alpha-aminopimelyl-epsilon-(D-2-aminoethyl)phosphonate | - |
Streptomyces sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptomyces sp. | the enzyme is responsible for the final peptidoglycan cross-linking step in bacterial cell wall biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces sp. | P15555 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | specific substrate binding to the peptidase induces a conformational change in the active site that places Ser62 in an optimal position for catalysis. This activated conformation relaxes as the reaction proceeds | Streptomyces sp. | ? | - |
? | |
additional information | the enzyme is responsible for the final peptidoglycan cross-linking step in bacterial cell wall biosynthesis | Streptomyces sp. | ? | - |
? |