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Literature summary for 3.4.16.4 extracted from

  • Wright, G.D.; Molinas, C.; Arthur, M.; Courvalin, P.; Walsh, C.T.
    Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147 (1992), Antimicrob. Agents Chemother., 36, 1514-1518.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Enterococcus faecium

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition: penicillin G, ampicillin, cephalosporin C Enterococcus faecium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, SDS-PAGE Enterococcus faecium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Enterococcus faecium
-
?
-
?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Enterococcus faecium BM4147
-
?
-
?

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
BM 4147
-
Enterococcus faecium BM4147
-
BM 4147
-

Reaction

Reaction Comment Organism Reaction ID
Preferential cleavage: (Ac)2-L-Lys-D-Ala-/-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine VanY, carboxypeptidase activity exclusively Enterococcus faecium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
Enterococcus faecium ?
-
?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
Enterococcus faecium BM4147 ?
-
?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
Enterococcus faecium UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
Enterococcus faecium BM4147 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Enterococcus faecium