Inhibitors | Comment | Organism | Structure |
---|---|---|---|
penicillin | kinetic model of interaction | Actinomadura sp. | |
penicillin | kinetic model of interaction | Streptomyces sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala | 54000 MW enzyme | Streptomyces sp. | |
12 | - |
Nalpha, Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala | lysozyme releasable enzyme | Streptomyces sp. | |
14 | - |
Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala | - |
Streptomyces sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Streptomyces sp. | - |
- |
extracellular | - |
Actinomadura sp. | - |
- |
membrane | - |
Streptomyces sp. | 16020 | - |
membrane | - |
Actinomadura sp. | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
gel filtration + mercaptoethanol, SDS-PAGE | Streptomyces sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine | Streptomyces sp. | - |
? | - |
? | |
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine | Actinomadura sp. | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Actinomadura sp. | - |
R39 | - |
Streptomyces sp. | - |
R61 | - |
Streptomyces sp. | - |
sp. K15 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture filtrate | - |
Streptomyces sp. | - |
culture filtrate | - |
Actinomadura sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly | acceptors in transpeptidase reaction | Streptomyces sp. | Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala | - |
ir | |
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O | - |
Streptomyces sp. | Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine | - |
? | |
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O | - |
Actinomadura sp. | Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine | - |
? | |
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-lactate + H2O | - |
Streptomyces sp. | Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-lactate | - |
? | |
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine | - |
Streptomyces sp. | ? | - |
? | |
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine | - |
Actinomadura sp. | ? | - |
? | |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O | - |
Streptomyces sp. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine | - |
? | |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O | - |
Actinomadura sp. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
ratio of hydrolysis/transpeptidation depending on pH | Streptomyces sp. |
additional information | - |
ratio of hydrolysis/transpeptidation depending on pH | Actinomadura sp. |
6 | 8 | hydrolysis, value increased by high ionic strength | Streptomyces sp. |
6 | 8 | hydrolysis, value increased by high ionic strength | Actinomadura sp. |
8 | - |
transpeptidation, Streptomyces sp. R61 | Streptomyces sp. |
9.5 | - |
transpeptidation, Streptomyces sp. R39 | Streptomyces sp. |