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Literature summary for 3.4.16.2 extracted from

  • Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
    Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator (2002), J. Biol. Chem., 277, 17962-17969.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II IC50: 0.002 mM Homo sapiens
antipain IC50: 0.002 mM Homo sapiens
benzyloxycarbonyl-Pro-Pro-aldehyde dimethyl acetal IC50: 0.001 mM Homo sapiens
bradykinin IC50: 0.1 mM Homo sapiens
corn trypsin inhibitor IC50: 40 nM Homo sapiens
diisopropyl fluorophosphate 1 mM Homo sapiens
HgCl2 IC50: 0.5 mM Homo sapiens
leupeptin 0.1 mM Homo sapiens
additional information benzamidine has no effect at 10 mM Homo sapiens
N-(9-fluorenyl)methoxycarbonyl-Ala-Pyr-CN IC50: 50 nM Homo sapiens
NEM 3 mM, 30% inhibition Homo sapiens
phenylmethyl sulfonyl fluoride 3 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000067
-
prekallikrein pH 7.1, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
CaCl2 optimal activity at 0.01 mM Homo sapiens
MgCl2 optimal activity at 1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell line
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prekallikrein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
endothelial cell prekallikrein activator
-
Homo sapiens
HUVEC PK activator
-
Homo sapiens
PKA
-
Homo sapiens
PRCP
-
Homo sapiens
prolylcarboxypeptidase
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
half-life: 240 min Homo sapiens
95
-
3 min, complete loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.8 7.4 more than 75% of maximal activity at pH 6.8 and pH 7.4 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
IC50: 40 nM Homo sapiens corn trypsin inhibitor
0.00005
-
IC50: 50 nM Homo sapiens N-(9-fluorenyl)methoxycarbonyl-Ala-Pyr-CN
0.001
-
IC50: 0.001 mM Homo sapiens benzyloxycarbonyl-Pro-Pro-aldehyde dimethyl acetal
0.002
-
IC50: 0.002 mM Homo sapiens antipain
0.002
-
IC50: 0.002 mM Homo sapiens angiotensin II
0.1
-
IC50: 0.1 mM Homo sapiens bradykinin
0.5
-
IC50: 0.5 mM Homo sapiens HgCl2