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Literature summary for 3.4.15.1 extracted from

  • Kase, R.; Hazato, T.; Shimamura, M.; Kiuchi, Y.; Katayama, T.
    Enkephalin-degrading dipeptidyl carboxypeptidase in guinea pig serum: its properties and action on bioactive peptides (1985), Arch. Biochem. Biophys., 240, 330-336.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Cavia porcellus
angiotensin II
-
 Cavia porcellus
angiotensin III
-
 Cavia porcellus
captopril
-
 Cavia porcellus
EDTA
-
 Cavia porcellus
gastrin I
-
 Cavia porcellus
PCMB
-
 Cavia porcellus
phosphoramidon
-
 Cavia porcellus
secretin
-
 Cavia porcellus
Substance P
-
 Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 Met-enkephalin
-
 Cavia porcellus
0.5
-
 Leu-enkephalin
-
 Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cavia porcellus the enzyme may play a role not only in the angiotensin-bradykinin system but also in the metabolism of circulating enkephalins and other bioactive peptides ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1128
-
-
 Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Cavia porcellus angiotensin II + His-Leu
-
 ?
bradykinin + H2O
-
 Cavia porcellus Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
Leu5-enkephalin + H2O
-
 Cavia porcellus Tyr-Gly-Gly + Phe-Leu
-
 ?
Met5-enkephalin + H2O
-
 Cavia porcellus Tyr-Gly-Gly + Phe-Met
-
 ?
additional information the enzyme may play a role not only in the angiotensin-bradykinin system but also in the metabolism of circulating enkephalins and other bioactive peptides Cavia porcellus ?
-
 ?
Tyr-Gly-Gly + H2O
-
 Cavia porcellus Tyr + Gly-Gly
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
-
 Cavia porcellus