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Literature summary for 3.4.15.1 extracted from

  • Hooper, N.M.; Turner, A.J.
    Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism (1987), Biochem. J., 241, 625-633.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
enalaprilate
-
 Sus scrofa
lisinopril
-
 Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
 x * 170000, one enzyme form from striatum, SDS-PAGE Sus scrofa
180000
-
 x * 180000, one enzyme form from striatum and kindey enzyme Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification the 180000 Da enzyme form contains approximately 17% carbohydrate Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain striatum, 2 enzyme forms: MW 170000 Da and MW 180000 Da Sus scrofa
-
kidney one enzyme form of 180000 Da Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.766
-
-
 Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Sus scrofa angiotensin II + His-Leu
-
 ?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O primary cleavage of Phe8-Gly9 Sus scrofa Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2
-
 ?
benzoyl-Gly-His-Leu + H2O
-
 Sus scrofa benzoyl-Gly + His-Leu
-
 ?
bradykinin + H2O
-
 Sus scrofa Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
[D-Ala2,Leu5]enkephalin + H2O
-
 Sus scrofa Tyr-D-Ala-Gly + Phe-Leu
-
 ?

Subunits

Subunits Comment Organism
? x * 180000, one enzyme form from striatum and kindey enzyme Sus scrofa
? x * 170000, one enzyme form from striatum, SDS-PAGE Sus scrofa