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Literature summary for 3.4.15.1 extracted from

  • Takada, Y.; Hiwada, K.; Kokubu, T.
    Isolation and characterization of angiotensin converting enzyme from human kidney (1981), J. Biochem., 90, 1309-1319.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
2,3-dimercapto-1-propanol
-
Homo sapiens
2-mercaptoethanol
-
Homo sapiens
8-hydroxyquinoline
-
Homo sapiens
bradykinin potentiator C
-
Homo sapiens
captopril
-
Homo sapiens
dithiothreitol
-
Homo sapiens
EDTA
-
Homo sapiens
guanethidine weak Homo sapiens
SDS weak Homo sapiens
Teprotide
-
Homo sapiens
Urea weak Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2
-
hippuryl-His-Leu
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
x * 170000, kidney, SDS-PAGE of the reduced enzyme Homo sapiens
199000
-
equilibrium sedimentation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Homo sapiens
side-chain modification 13% neutral sugar Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?

Subunits

Subunits Comment Organism
? x * 170000, kidney, SDS-PAGE of the reduced enzyme Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
5-30 min, stable Homo sapiens
50
-
10 min, 60% loss of activity Homo sapiens
55
-
10 min, 80% loss of activity Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
545
-
hippuryl-His-Leu
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2 8.4 hydrolysis of hippuryl-His-Leu Homo sapiens