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Literature summary for 3.4.15.1 extracted from

  • Ondetti, M.A.; Cushman, D.W.
    Enzymes of the renin-angiotensin system and their inhibitors (1982), Annu. Rev. Biochem., 51, 283-308.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information
-
Bos taurus
additional information
-
Canis lupus familiaris
additional information
-
Cavia porcellus
additional information
-
Homo sapiens
additional information
-
Oryctolagus cuniculus
additional information
-
Papio anubis
additional information
-
Rattus norvegicus
additional information
-
Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc
-
Homo sapiens
Zinc contains 0.8 gatom of zinc per mol of enzyme Oryctolagus cuniculus
Zinc contains 1.2 gatom of zinc per mol of enzyme Equus caballus
Zinc contains 0.9 gatom of zinc per mol of enzyme Canis lupus familiaris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113000
-
gel filtration Equus caballus
126000
-
x * 126000, enzyme from lung, SDS-PAGE with 7% acryl amide Bos taurus
130000
-
x * 130000, enzyme from lung, SDS-PAGE with 7% acryl amide Homo sapiens
139000
-
x * 139000, SDS-PAGE with 7% acryl amide Rattus norvegicus
139000
-
x * 139000, SDS-PAGE with 7% acryl amide Sus scrofa
140000
-
x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Homo sapiens
140000
-
x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
140000
-
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
140000
-
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Canis lupus familiaris
165000
-
x * 165000, SDS-PAGE with 5% acryl amide Homo sapiens
180000
-
-
Homo sapiens
180000
-
gel filtration Bos taurus
180000
-
x * 180000, enzyme from lung, SDS-PAGE with 5% acryl amide Oryctolagus cuniculus
195000
-
x * 195000, enzyme from kidney, SDS-PAGE with 5% acryl amide Sus scrofa
206000
-
x * 206000, enzyme from lung, SDS-PAGE with 5% acryl amide Sus scrofa
270000
-
gel filtration Rattus norvegicus
290000
-
enzyme from lung and protstate, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Equus caballus
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Papio anubis
-
baboon
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Cavia porcellus
side-chain modification glycoprotein Homo sapiens
side-chain modification glycoprotein Rattus norvegicus
side-chain modification glycoprotein Sus scrofa
side-chain modification glycoprotein Bos taurus
side-chain modification glycoprotein Oryctolagus cuniculus
side-chain modification glycoprotein Canis lupus familiaris
side-chain modification lung enzyme contains 16-29% carbohydrate, enzyme from serum contains 32% carbohydrate Oryctolagus cuniculus
side-chain modification contains 17% carbohydrate Canis lupus familiaris
side-chain modification contains 8% carbohydrate Rattus norvegicus
side-chain modification contains 8% carbohydrate Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
kidney
-
Bos taurus
-
kidney
-
Oryctolagus cuniculus
-
lung
-
Cavia porcellus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
lung
-
Sus scrofa
-
lung
-
Bos taurus
-
lung
-
Oryctolagus cuniculus
-
lung
-
Canis lupus familiaris
-
lung
-
Papio anubis
-
plasma
-
Homo sapiens
-
plasma
-
Sus scrofa
-
plasma
-
Equus caballus
-
prostate gland
-
Homo sapiens
-
semen
-
Homo sapiens
-
semen
-
Bos taurus
-
serum
-
Homo sapiens
-
serum
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-His-Leu + H2O
-
Bos taurus benzyloxycarbonyl-Phe + His-Leu
-
?
hippuryl-Gly-Gly + H2O
-
Homo sapiens hippuric acid + Gly-Gly
-
?
hippuryl-Gly-Gly + H2O
-
Sus scrofa hippuric acid + Gly-Gly
-
?
hippuryl-His-Leu + H2O
-
Cavia porcellus hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Rattus norvegicus hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Sus scrofa hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Bos taurus hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Oryctolagus cuniculus hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Canis lupus familiaris hippuric acid + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Papio anubis hippuric acid + His-Leu
-
?

Subunits

Subunits Comment Organism
? x * 139000, SDS-PAGE with 7% acryl amide Rattus norvegicus
? x * 139000, SDS-PAGE with 7% acryl amide Sus scrofa
? x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Homo sapiens
? x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
? x * 180000, enzyme from lung, SDS-PAGE with 5% acryl amide Oryctolagus cuniculus
? x * 195000, enzyme from kidney, SDS-PAGE with 5% acryl amide Sus scrofa
? x * 206000, enzyme from lung, SDS-PAGE with 5% acryl amide Sus scrofa
? x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
? x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Canis lupus familiaris
? x * 165000, SDS-PAGE with 5% acryl amide Homo sapiens
? x * 130000, enzyme from lung, SDS-PAGE with 7% acryl amide Homo sapiens
? x * 126000, enzyme from lung, SDS-PAGE with 7% acryl amide Bos taurus