Protein Variants | Comment | Organism |
---|---|---|
additional information | lentivirus-mediated shRNA knockdown of somatic ACE, sAce | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | ACE competitive inhibitor, inhibits somatic ACE activity. Captopril significantly lowers the percentage of cells in the S phase and significantly increases the percentage of cells in the G0/G1 phase compared with the negative control, whereas the percentage of cells in each cell cycle phase nearly recovers following captopril withdrawal | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | associated, sACE | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | ACE is a zinc dipeptidyl carboxypeptidase | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Mus musculus | - |
angiotensin II + L-His-L-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P09470 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatogonial stem cell | spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse cultured spermatogonial stem cells (SSCs) | Mus musculus | - |
testis | spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse testis before postpartum day 7 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Mus musculus | angiotensin II + L-His-L-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Mus musculus |
angiotensin I-converting enzyme | - |
Mus musculus |
sACE | - |
Mus musculus |
TACE | - |
Mus musculus |
zinc dipeptidyl carboxypeptidase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | sAce knockdown through shRNAs impairs proliferation of mouse spermatogonial stem cells in vitro and leads to smaller colony size | Mus musculus |
metabolism | angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system | Mus musculus |
physiological function | ACE is a well-characterized zinc peptidase that removes C-terminal dipeptides from substrates such as angiotensin I and bradykinin leading to an increase in blood pressure. Angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system. Somatic ACE, sACE, plays an important role in spermatogonial stem cell (SSC) self-renewal through the regulation of MAPK-dependent cell proliferation. sACE is required for the self-renewal of SSCs through the MAPK signaling pathway | Mus musculus |