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Literature summary for 3.4.15.1 extracted from

  • Gao, T.; Zhao, X.; Liu, C.; Shao, B.; Zhang, X.; Li, K.; Cai, J.; Wang, S.; Huang, X.
    Somatic angiotensin I-converting enzyme regulates self-renewal of mouse spermatogonial stem cells through the mitogen-activated protein kinase signaling pathway (2018), Stem Cells Dev., 27, 1021-1032 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information lentivirus-mediated shRNA knockdown of somatic ACE, sAce Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
captopril ACE competitive inhibitor, inhibits somatic ACE activity. Captopril significantly lowers the percentage of cells in the S phase and significantly increases the percentage of cells in the G0/G1 phase compared with the negative control, whereas the percentage of cells in each cell cycle phase nearly recovers following captopril withdrawal Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated, sACE Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ ACE is a zinc dipeptidyl carboxypeptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Mus musculus
-
angiotensin II + L-His-L-Leu
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P09470
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatogonial stem cell spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse cultured spermatogonial stem cells (SSCs) Mus musculus
-
testis spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse testis before postpartum day 7 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Mus musculus angiotensin II + L-His-L-Leu
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Mus musculus
angiotensin I-converting enzyme
-
Mus musculus
sACE
-
Mus musculus
TACE
-
Mus musculus
zinc dipeptidyl carboxypeptidase
-
Mus musculus

General Information

General Information Comment Organism
malfunction sAce knockdown through shRNAs impairs proliferation of mouse spermatogonial stem cells in vitro and leads to smaller colony size Mus musculus
metabolism angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system Mus musculus
physiological function ACE is a well-characterized zinc peptidase that removes C-terminal dipeptides from substrates such as angiotensin I and bradykinin leading to an increase in blood pressure. Angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system. Somatic ACE, sACE, plays an important role in spermatogonial stem cell (SSC) self-renewal through the regulation of MAPK-dependent cell proliferation. sACE is required for the self-renewal of SSCs through the MAPK signaling pathway Mus musculus