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Literature summary for 3.4.15.1 extracted from
- Tissue specificity of human angiotensin I-converting enzyme (2015), PLoS ONE, 10, e0143455 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| enalaprilat | - |
Homo sapiens |  |
| additional information | inhibition of ACE activity with anti-catalytic anti-ACE monoclonal antibodies, development and inhibition analysis with enzyme from different tissues, overview | Homo sapiens | |
| Teprotide | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | membrane-bound on the surface of epithelial cells of epididymis and prostate | Homo sapiens | 9986 | - |
| membrane | membrane-bound | Homo sapiens | 16020 | - |
| soluble | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | the enzyme is a Zn2+ peptidyldipeptidase | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | Homo sapiens | - |
angiotensin II + L-His-L-Leu | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P12821 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| sialoglycoprotein | angiotensin-converting enzyme (ACE) is expressed as a type-1 membrane glycoprotein on the surface of endothelial and epithelial cells. Desialylation of ACE is performed by comercial neuraminidase from Vibrio cholerae at pH 6.0, 25°C. While desialylation of seminal fluid ACE does not result in the appearance of any neuraminic acid on the ion-exchange chromatogram, desialylation of lung ACE results in the appearance of 5 neuraminic acid residues per molecule of the enzyme. N-glycosylation sites on the N and C domains of human ACE is analyzed by mass spectrometry, detailed overview. Effect of inactivated human plasma on mAbs binding to two types of ACE differed significantly, with seminal fluid ACE being more sensitive to the presence of plasma. Effect of inactivated seminal fluid on mAbs binding to two types of ACE also showed more prominent effect for seminal fluid ACE, strengthening the suggestion that different conformations of these ACEs can participate in different regulation of the functions of ACEs on endothelial and epithelial cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | soluble form | Homo sapiens | - |
| endothelial cell | membrane-bound form | Homo sapiens | - |
| epididymis | - |
Homo sapiens | - |
| epithelial cell | membrane-bound form, surface of epithelial cells of epididymis and prostate | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | angiotensin-converting enzyme (ACE) is expressed as a type-1 membrane glycoprotein on the surface of endothelial and epithelial cells. ACE is also presents as a soluble form in biological fluids, among which seminal fluid being the richest in ACE content with 50fold higher content compared to blood | Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| seminal plasma | soluble form | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + L-His-L-Leu | - |
? | |
| Hip-His-Leu + H2O | - |
Homo sapiens | ? | - |
? | |
| N-benzyloxycarbonyl-Phe-His-Leu + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-Phe + His-Leu | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE | - |
Homo sapiens |
| angiotensin I-converting enzyme | - |
Homo sapiens |
| CD143 | - |
Homo sapiens |
| Zn2+ peptidyldipeptidase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | - |
assay at | Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | lung enzyme | - |
5.1 |
| Homo sapiens | kidney enzyme | - |
5.2 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | conformational fingerprinting of ACE from different tissues/subcellular compartments, i.e. lung and seminal fluid, using anti-catalytic anti-ACE monoclonal antibodies, overview | Homo sapiens |
| physiological function | angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, as well as in reproductive functions | Homo sapiens |
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