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Literature summary for 3.4.15.1 extracted from

  • Chollet, C.; Placier, S.; Chatziantoniou, C.; Hus-Citharel, A.; Caron, N.; Roussel, R.; Alhenc-Gelas, F.; Bouby, N.
    Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice (2018), Am. J. Physiol. Heart Circ. Physiol., 314, H350-H358 .
    View publication on PubMed
Search for more literature for 3.4.15.1

Protein Variants

Protein Variants Comment Organism
additional information generation of genetically engineered mice carrying a duplication of the ACE gene on chromosome 11 on a C57Bl6/J background, the littermate mice carry three (heterozygote for the duplication) functional ACE gene copies. Phenotype and regulatory effects of the mutation, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Mus musculus
-
-
membrane
-
 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus P09470
-
-
Mus musculus C57Bl6/J P09470
-
-

Source Tissue

Source Tissue Comment Organism Textmining
arteriole
-
 Mus musculus
-
artery
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
ACE
-
 Mus musculus
angiotensin I-converting enzyme
-
 Mus musculus
Dcp1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction genetically modified mice carrying three copies of the ACE gene (three-copy mice) show increased angiotensin I-converting enzyme which alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice. Mice with three copies of the ACE gene and a moderate genetic increase in ACE synthesis display abnormal systemic and renal hemodynamic responses to ANGII. No ACE genotype effect on the blood pressure response is observed for vasoconstrictor norepinephrine. The increase in endogenous ANG II formation due to increased ACE activity does not result in desensitization to the peptide's effect through downregulation of ANG II type 1 (AT1) receptor synthesis. Regulatory effects of the mutation, overview Mus musculus
physiological function ACE is an endothelial ectopeptidase that is also secreted in plasma Mus musculus