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Literature summary for 3.4.15.1 extracted from

  • Adam, A.; Leclair, P.; Montpas, N.; Koumbadinga, G.A.; Bachelard, H.; Marceau, F.
    Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases (2010), Neuropeptides, 44, 69-75.
    View publication on PubMed

Application

Application Comment Organism
drug development ACE is the molecular targets of inhibitory drugs that favorably influence diabetic complications Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
enalaprilat inhibits ACE and the bradykinin degradation in vivo, which is reversed by insulin Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Rattus norvegicus bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors ?
-
?
additional information Rattus norvegicus ACE degrades bradykinin, other vasoactive peptides, and activates angiotensin ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Zucker rats and Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
heart heart membrane, ACE activity is significantly higher in hearts of young Zucker rats than in those of Sprague-Dawley rats Rattus norvegicus
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myocardium
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
Rattus norvegicus ?
-
?
bradykinin + H2O bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors Rattus norvegicus ?
-
?
additional information ACE degrades bradykinin, other vasoactive peptides, and activates angiotensin Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus ACE activity is significantly decreased in heart membranes 4-8 weeks post-streptozotocin injection down

General Information

General Information Comment Organism
physiological function peptidases angiotensin-converting enzyme, together with neutral endopeptidase 24.11, mediates most of the kinin catabolism in normal cardiac tissue Rattus norvegicus