Application | Comment | Organism |
---|---|---|
drug development | ACE is the molecular targets of inhibitory drugs that favorably influence diabetic complications | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
enalaprilat | inhibits ACE and the bradykinin degradation in vivo, which is reversed by insulin | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | Rattus norvegicus | bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors | ? | - |
? | |
additional information | Rattus norvegicus | ACE degrades bradykinin, other vasoactive peptides, and activates angiotensin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Zucker rats and Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | heart membrane, ACE activity is significantly higher in hearts of young Zucker rats than in those of Sprague-Dawley rats | Rattus norvegicus | - |
myocardium | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
bradykinin + H2O | bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors | Rattus norvegicus | ? | - |
? | |
additional information | ACE degrades bradykinin, other vasoactive peptides, and activates angiotensin | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | ACE activity is significantly decreased in heart membranes 4-8 weeks post-streptozotocin injection | down |
General Information | Comment | Organism |
---|---|---|
physiological function | peptidases angiotensin-converting enzyme, together with neutral endopeptidase 24.11, mediates most of the kinin catabolism in normal cardiac tissue | Rattus norvegicus |