Application | Comment | Organism |
---|---|---|
medicine | ACE is an ideal target, clinically and nutritionally, in the treatment of hypertension | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ala-Phe | - |
Homo sapiens | |
Ala-Pro-Gly-Ala-Gly-Val-Tyr | - |
Homo sapiens | |
Ala-Trp-Pro-Phe | - |
Homo sapiens | |
Ala-Tyr | - |
Homo sapiens | |
Asn-Phe | - |
Homo sapiens | |
Asn-Trp-Gly-Pro-Leu-Val | - |
Homo sapiens | |
Asn-Tyr | - |
Homo sapiens | |
Asp-Gly | - |
Homo sapiens | |
Asp-Ile-Gly-Tyr-Tyr | - |
Homo sapiens | |
Asp-Leu-Pro | - |
Homo sapiens | |
Asp-Tyr-Val-Gly-Asn | - |
Homo sapiens | |
captopril | - |
Homo sapiens | |
Gly-Glu-Pro | - |
Homo sapiens | |
Gly-Gly-Val-Ile-Pro-Asn | - |
Homo sapiens | |
Gly-Pro-Pro | - |
Homo sapiens | |
Gly-Tyr | - |
Homo sapiens | |
His-His-Leu | - |
Homo sapiens | |
Ile-Ala | - |
Homo sapiens | |
Ile-Ala-Tyr-Lys-Pro-Ala-Gly | - |
Homo sapiens | |
Ile-Asn-Ser-Gln | - |
Homo sapiens | |
Ile-Phe-Leu | - |
Homo sapiens | |
Ile-Pro-Pro-Gly-Val-Pro-Tyr | - |
Homo sapiens | |
Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr | - |
Homo sapiens | |
Ile-Thr-Phe | - |
Homo sapiens | |
Ile-Tyr | - |
Homo sapiens | |
Ile-Tyr-Leu-Leu | - |
Homo sapiens | |
Ile-Val-Tyr | - |
Homo sapiens | |
Leu-Ala-Ile-pro-Val-Asn-Lys-Pro | - |
Homo sapiens | |
Leu-Arg-Ile-Pro-Val-Ala | - |
Homo sapiens | |
Leu-Gly-Ile | - |
Homo sapiens | |
Leu-Phe | - |
Homo sapiens | |
Leu-Tyr | - |
Homo sapiens | |
Lys-Asp-Tyr-Arg-Leu | - |
Homo sapiens | |
Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe | - |
Homo sapiens | |
Met-Arg-Trp | - |
Homo sapiens | |
Met-Arg-Trp-Arg-Asp | - |
Homo sapiens | |
additional information | mass spectrometric and structural analysis, and production and purification of plant food-derived ACE inhibitory peptides, bioactivities, overview | Homo sapiens | |
Phe-Phe-Leu | - |
Homo sapiens | |
Phe-Tyr | - |
Homo sapiens | |
Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser | - |
Homo sapiens | |
Pro-Asn-Asn-Lys-Pro-Phe-Gln | - |
Homo sapiens | |
Pro-Ser-Tyr | - |
Homo sapiens | |
Ser-Phe | - |
Homo sapiens | |
Ser-Trp-Ser-Phe | - |
Homo sapiens | |
Ser-Tyr | - |
Homo sapiens | |
Thr-Ala-Pro-Tyr | - |
Homo sapiens | |
Thr-Gln-Val-Tyr | - |
Homo sapiens | |
Thr-Phe | - |
Homo sapiens | |
Thr-Tyr-Leu-Gly-Ser | - |
Homo sapiens | |
Thr-Val-Pro-Tyr | - |
Homo sapiens | |
Thr-Val-Val-Pro-Gly | - |
Homo sapiens | |
Trp-Leu | - |
Homo sapiens | |
Trp-Val-Pro-Ser-Val-Tyr | - |
Homo sapiens | |
Tyr-Gln-Tyr | - |
Homo sapiens | |
Tyr-Leu | - |
Homo sapiens | |
Tyr-Leu-Ala-Gly-Asn-Gln | - |
Homo sapiens | |
Tyr-Pro-Lys | - |
Homo sapiens | |
Tyr-Tyr-Ala-Pro-Phe | - |
Homo sapiens | |
Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu | - |
Homo sapiens | |
Tyr-Val-Val-Phe-Lys | - |
Homo sapiens | |
Val-Ile-Glu-Lys-Tyr-Pro | - |
Homo sapiens | |
Val-Leu-Ile-Val-Pro | - |
Homo sapiens | |
Val-Lys | - |
Homo sapiens | |
Val-Met-Asp-Lys-Pro-Gln-Gly | - |
Homo sapiens | |
Val-Phe | - |
Homo sapiens | |
Val-Phe-Pro-Tyr | - |
Homo sapiens | |
Val-Thr-Pro-Ala-Leu-Arg | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cl- | the activity of the C-domain of sACE depends highly on chloride ion concentration and is inactive in its absence, whereas the N-domain can be completely activated at relatively low concentrations of this anion and is still active in the absence of chloride | Homo sapiens | |
Zn2+ | ACE is a metallopeptidase. An activated water molecule complexed to Zn2+ acts as the nucleophile to attack the carbonyl group of the targeted peptide bond | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? | |
bradykinin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
somatic and germinal isozymes, sACE and gACE | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | isozyme domain structures with N- and C-domains and the HEXXH motif, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Homo sapiens |
angiotensin I converting enzyme | - |
Homo sapiens |
gACE | - |
Homo sapiens |
germinal ACE | - |
Homo sapiens |
More | ACE is a M2 family metallopeptidase | Homo sapiens |
sACE | - |
Homo sapiens |
somatic ACE | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00038 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Arg-Ile-Pro-Val-Ala | |
0.00046 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Phe-Pro-Tyr | |
0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Leu-Pro | |
0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Val-Tyr | |
0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | Met-Arg-Trp | |
0.00072 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Tyr-Val-Gly-Asn | |
0.00074 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Gly-Val-Ile-Pro-Asn | |
0.00086 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Tyr-Leu-Gly-Ser | |
0.00169 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Leu-Ile-Val-Pro | |
0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Pro-Gly-Ala-Gly-Val-Tyr | |
0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Val-Pro-Tyr | |
0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Tyr | |
0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | Met-Arg-Trp-Arg-Asp | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | His-His-Leu | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Val-Val-Pro-Gly | |
0.0027 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Pro-Gly-Ala-Gly-Val-Tyr | |
0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Ile-Gly-Tyr-Tyr | |
0.00374 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Tyr | |
0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Gln-Tyr | |
0.0042 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Tyr-Lys-Pro-Ala-Gly | |
0.00625 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Pro-Pro | |
0.0064 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Tyr | |
0.0069 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser | |
0.0092 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Phe | |
0.0105 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Pro-Lys | |
0.0123 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Gly | |
0.013 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Lys | |
0.0134 | - |
pH and temperature not specified in the publication | Homo sapiens | Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe | |
0.0136 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Ala-Pro-Tyr | |
0.014 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Leu-Ala-Gly-Asn-Gln | |
0.0142 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Tyr | |
0.0151 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Phe | |
0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | Pro-Ser-Tyr | |
0.0164 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Leu | |
0.0175 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Pro-Pro-Gly-Val-Pro-Tyr | |
0.0178 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Phe | |
0.0182 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Gln-Val-Tyr | |
0.0183 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Trp-Pro-Phe | |
0.021 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Trp-Gly-Pro-Leu-Val | |
0.025 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Tyr | |
0.0257 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Val-Pro-Ser-Val-Tyr | |
0.0264 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Tyr-Ala-Pro-Phe | |
0.0265 | - |
pH and temperature not specified in the publication | Homo sapiens | Lys-Asp-Tyr-Arg-Leu | |
0.029 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Gly-Ile | |
0.0299 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Leu | |
0.0326 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Tyr | |
0.033 | - |
pH and temperature not specified in the publication | Homo sapiens | Pro-Asn-Asn-Lys-Pro-Phe-Gln | |
0.037 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Phe-Leu | |
0.039 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Met-Asp-Lys-Pro-Gln-Gly | |
0.039 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Thr-Phe | |
0.04 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Glu-Pro | |
0.041 | - |
pH and temperature not specified in the publication | Homo sapiens | captopril | |
0.042 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Tyr-Leu-Leu | |
0.044 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Val-Val-Phe-Lys | |
0.0448 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Phe-Leu | |
0.046 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Asn-Ser-Gln | |
0.0463 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Phe | |
0.064 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr | |
0.065 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Leu | |
0.0663 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Tyr | |
0.07 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Ala-Ile-pro-Val-Asn-Lys-Pro | |
0.0721 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Tyr | |
0.0763 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Trp-Ser-Phe | |
0.0824 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Thr-Pro-Ala-Leu-Arg | |
0.083 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu | |
0.097 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Ile-Glu-Lys-Tyr-Pro | |
0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Tyr | |
0.126 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Phe | |
0.1302 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Phe | |
0.153 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala |
General Information | Comment | Organism |
---|---|---|
physiological function | angiotensin I-converting enzyme, ACE, catalyzes the formation of vasoconstrictor, angiotensin II, and the inactivation of vasodilator, bradykinin | Homo sapiens |