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Literature summary for 3.4.15.1 extracted from

  • Guang, C.; Phillips, R.D.
    Plant food-derived angiotensin I converting enzyme inhibitory peptides (2009), J. Agric. Food Chem., 57, 5113-5120.
    View publication on PubMed

Application

Application Comment Organism
medicine ACE is an ideal target, clinically and nutritionally, in the treatment of hypertension Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ala-Phe
-
Homo sapiens
Ala-Pro-Gly-Ala-Gly-Val-Tyr
-
Homo sapiens
Ala-Trp-Pro-Phe
-
Homo sapiens
Ala-Tyr
-
Homo sapiens
Asn-Phe
-
Homo sapiens
Asn-Trp-Gly-Pro-Leu-Val
-
Homo sapiens
Asn-Tyr
-
Homo sapiens
Asp-Gly
-
Homo sapiens
Asp-Ile-Gly-Tyr-Tyr
-
Homo sapiens
Asp-Leu-Pro
-
Homo sapiens
Asp-Tyr-Val-Gly-Asn
-
Homo sapiens
captopril
-
Homo sapiens
Gly-Glu-Pro
-
Homo sapiens
Gly-Gly-Val-Ile-Pro-Asn
-
Homo sapiens
Gly-Pro-Pro
-
Homo sapiens
Gly-Tyr
-
Homo sapiens
His-His-Leu
-
Homo sapiens
Ile-Ala
-
Homo sapiens
Ile-Ala-Tyr-Lys-Pro-Ala-Gly
-
Homo sapiens
Ile-Asn-Ser-Gln
-
Homo sapiens
Ile-Phe-Leu
-
Homo sapiens
Ile-Pro-Pro-Gly-Val-Pro-Tyr
-
Homo sapiens
Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr
-
Homo sapiens
Ile-Thr-Phe
-
Homo sapiens
Ile-Tyr
-
Homo sapiens
Ile-Tyr-Leu-Leu
-
Homo sapiens
Ile-Val-Tyr
-
Homo sapiens
Leu-Ala-Ile-pro-Val-Asn-Lys-Pro
-
Homo sapiens
Leu-Arg-Ile-Pro-Val-Ala
-
Homo sapiens
Leu-Gly-Ile
-
Homo sapiens
Leu-Phe
-
Homo sapiens
Leu-Tyr
-
Homo sapiens
Lys-Asp-Tyr-Arg-Leu
-
Homo sapiens
Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe
-
Homo sapiens
Met-Arg-Trp
-
Homo sapiens
Met-Arg-Trp-Arg-Asp
-
Homo sapiens
additional information mass spectrometric and structural analysis, and production and purification of plant food-derived ACE inhibitory peptides, bioactivities, overview Homo sapiens
Phe-Phe-Leu
-
Homo sapiens
Phe-Tyr
-
Homo sapiens
Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser
-
Homo sapiens
Pro-Asn-Asn-Lys-Pro-Phe-Gln
-
Homo sapiens
Pro-Ser-Tyr
-
Homo sapiens
Ser-Phe
-
Homo sapiens
Ser-Trp-Ser-Phe
-
Homo sapiens
Ser-Tyr
-
Homo sapiens
Thr-Ala-Pro-Tyr
-
Homo sapiens
Thr-Gln-Val-Tyr
-
Homo sapiens
Thr-Phe
-
Homo sapiens
Thr-Tyr-Leu-Gly-Ser
-
Homo sapiens
Thr-Val-Pro-Tyr
-
Homo sapiens
Thr-Val-Val-Pro-Gly
-
Homo sapiens
Trp-Leu
-
Homo sapiens
Trp-Val-Pro-Ser-Val-Tyr
-
Homo sapiens
Tyr-Gln-Tyr
-
Homo sapiens
Tyr-Leu
-
Homo sapiens
Tyr-Leu-Ala-Gly-Asn-Gln
-
Homo sapiens
Tyr-Pro-Lys
-
Homo sapiens
Tyr-Tyr-Ala-Pro-Phe
-
Homo sapiens
Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu
-
Homo sapiens
Tyr-Val-Val-Phe-Lys
-
Homo sapiens
Val-Ile-Glu-Lys-Tyr-Pro
-
Homo sapiens
Val-Leu-Ile-Val-Pro
-
Homo sapiens
Val-Lys
-
Homo sapiens
Val-Met-Asp-Lys-Pro-Gln-Gly
-
Homo sapiens
Val-Phe
-
Homo sapiens
Val-Phe-Pro-Tyr
-
Homo sapiens
Val-Thr-Pro-Ala-Leu-Arg
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cl- the activity of the C-domain of sACE depends highly on chloride ion concentration and is inactive in its absence, whereas the N-domain can be completely activated at relatively low concentrations of this anion and is still active in the absence of chloride Homo sapiens
Zn2+ ACE is a metallopeptidase. An activated water molecule complexed to Zn2+ acts as the nucleophile to attack the carbonyl group of the targeted peptide bond Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
angiotensin II + His-Leu
-
?
bradykinin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
somatic and germinal isozymes, sACE and gACE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
bradykinin + H2O
-
Homo sapiens ?
-
?
hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?

Subunits

Subunits Comment Organism
More isozyme domain structures with N- and C-domains and the HEXXH motif, overview Homo sapiens

Synonyms

Synonyms Comment Organism
ACE
-
Homo sapiens
angiotensin I converting enzyme
-
Homo sapiens
gACE
-
Homo sapiens
germinal ACE
-
Homo sapiens
More ACE is a M2 family metallopeptidase Homo sapiens
sACE
-
Homo sapiens
somatic ACE
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00038
-
pH and temperature not specified in the publication Homo sapiens Leu-Arg-Ile-Pro-Val-Ala
0.00046
-
pH and temperature not specified in the publication Homo sapiens Val-Phe-Pro-Tyr
0.00048
-
pH and temperature not specified in the publication Homo sapiens Asp-Leu-Pro
0.00048
-
pH and temperature not specified in the publication Homo sapiens Ile-Val-Tyr
0.0006
-
pH and temperature not specified in the publication Homo sapiens Met-Arg-Trp
0.00072
-
pH and temperature not specified in the publication Homo sapiens Asp-Tyr-Val-Gly-Asn
0.00074
-
pH and temperature not specified in the publication Homo sapiens Gly-Gly-Val-Ile-Pro-Asn
0.00086
-
pH and temperature not specified in the publication Homo sapiens Thr-Tyr-Leu-Gly-Ser
0.00169
-
pH and temperature not specified in the publication Homo sapiens Val-Leu-Ile-Val-Pro
0.0017
-
pH and temperature not specified in the publication Homo sapiens Ala-Pro-Gly-Ala-Gly-Val-Tyr
0.002
-
pH and temperature not specified in the publication Homo sapiens Thr-Val-Pro-Tyr
0.0021
-
pH and temperature not specified in the publication Homo sapiens Ile-Tyr
0.0021
-
pH and temperature not specified in the publication Homo sapiens Met-Arg-Trp-Arg-Asp
0.0022
-
pH and temperature not specified in the publication Homo sapiens His-His-Leu
0.0022
-
pH and temperature not specified in the publication Homo sapiens Thr-Val-Val-Pro-Gly
0.0027
-
pH and temperature not specified in the publication Homo sapiens Ala-Pro-Gly-Ala-Gly-Val-Tyr
0.0034
-
pH and temperature not specified in the publication Homo sapiens Asp-Ile-Gly-Tyr-Tyr
0.00374
-
pH and temperature not specified in the publication Homo sapiens Phe-Tyr
0.004
-
pH and temperature not specified in the publication Homo sapiens Tyr-Gln-Tyr
0.0042
-
pH and temperature not specified in the publication Homo sapiens Ile-Ala-Tyr-Lys-Pro-Ala-Gly
0.00625
-
pH and temperature not specified in the publication Homo sapiens Gly-Pro-Pro
0.0064
-
pH and temperature not specified in the publication Homo sapiens Leu-Tyr
0.0069
-
pH and temperature not specified in the publication Homo sapiens Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser
0.0092
-
pH and temperature not specified in the publication Homo sapiens Val-Phe
0.0105
-
pH and temperature not specified in the publication Homo sapiens Tyr-Pro-Lys
0.0123
-
pH and temperature not specified in the publication Homo sapiens Asp-Gly
0.013
-
pH and temperature not specified in the publication Homo sapiens Val-Lys
0.0134
-
pH and temperature not specified in the publication Homo sapiens Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe
0.0136
-
pH and temperature not specified in the publication Homo sapiens Thr-Ala-Pro-Tyr
0.014
-
pH and temperature not specified in the publication Homo sapiens Tyr-Leu-Ala-Gly-Asn-Gln
0.0142
-
pH and temperature not specified in the publication Homo sapiens Ala-Tyr
0.0151
-
pH and temperature not specified in the publication Homo sapiens Ala-Phe
0.016
-
pH and temperature not specified in the publication Homo sapiens Pro-Ser-Tyr
0.0164
-
pH and temperature not specified in the publication Homo sapiens Tyr-Leu
0.0175
-
pH and temperature not specified in the publication Homo sapiens Ile-Pro-Pro-Gly-Val-Pro-Tyr
0.0178
-
pH and temperature not specified in the publication Homo sapiens Thr-Phe
0.0182
-
pH and temperature not specified in the publication Homo sapiens Thr-Gln-Val-Tyr
0.0183
-
pH and temperature not specified in the publication Homo sapiens Ala-Trp-Pro-Phe
0.021
-
pH and temperature not specified in the publication Homo sapiens Asn-Trp-Gly-Pro-Leu-Val
0.025
-
pH and temperature not specified in the publication Homo sapiens Phe-Tyr
0.0257
-
pH and temperature not specified in the publication Homo sapiens Trp-Val-Pro-Ser-Val-Tyr
0.0264
-
pH and temperature not specified in the publication Homo sapiens Tyr-Tyr-Ala-Pro-Phe
0.0265
-
pH and temperature not specified in the publication Homo sapiens Lys-Asp-Tyr-Arg-Leu
0.029
-
pH and temperature not specified in the publication Homo sapiens Leu-Gly-Ile
0.0299
-
pH and temperature not specified in the publication Homo sapiens Trp-Leu
0.0326
-
pH and temperature not specified in the publication Homo sapiens Asn-Tyr
0.033
-
pH and temperature not specified in the publication Homo sapiens Pro-Asn-Asn-Lys-Pro-Phe-Gln
0.037
-
pH and temperature not specified in the publication Homo sapiens Phe-Phe-Leu
0.039
-
pH and temperature not specified in the publication Homo sapiens Val-Met-Asp-Lys-Pro-Gln-Gly
0.039
-
pH and temperature not specified in the publication Homo sapiens Ile-Thr-Phe
0.04
-
pH and temperature not specified in the publication Homo sapiens Gly-Glu-Pro
0.041
-
pH and temperature not specified in the publication Homo sapiens captopril
0.042
-
pH and temperature not specified in the publication Homo sapiens Ile-Tyr-Leu-Leu
0.044
-
pH and temperature not specified in the publication Homo sapiens Tyr-Val-Val-Phe-Lys
0.0448
-
pH and temperature not specified in the publication Homo sapiens Ile-Phe-Leu
0.046
-
pH and temperature not specified in the publication Homo sapiens Ile-Asn-Ser-Gln
0.0463
-
pH and temperature not specified in the publication Homo sapiens Asn-Phe
0.064
-
pH and temperature not specified in the publication Homo sapiens Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr
0.065
-
pH and temperature not specified in the publication Homo sapiens Trp-Leu
0.0663
-
pH and temperature not specified in the publication Homo sapiens Ser-Tyr
0.07
-
pH and temperature not specified in the publication Homo sapiens Leu-Ala-Ile-pro-Val-Asn-Lys-Pro
0.0721
-
pH and temperature not specified in the publication Homo sapiens Gly-Tyr
0.0763
-
pH and temperature not specified in the publication Homo sapiens Ser-Trp-Ser-Phe
0.0824
-
pH and temperature not specified in the publication Homo sapiens Val-Thr-Pro-Ala-Leu-Arg
0.083
-
pH and temperature not specified in the publication Homo sapiens Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu
0.097
-
pH and temperature not specified in the publication Homo sapiens Val-Ile-Glu-Lys-Tyr-Pro
0.1
-
pH and temperature not specified in the publication Homo sapiens Ala-Tyr
0.126
-
pH and temperature not specified in the publication Homo sapiens Leu-Phe
0.1302
-
pH and temperature not specified in the publication Homo sapiens Ser-Phe
0.153
-
pH and temperature not specified in the publication Homo sapiens Ile-Ala

General Information

General Information Comment Organism
physiological function angiotensin I-converting enzyme, ACE, catalyzes the formation of vasoconstrictor, angiotensin II, and the inactivation of vasodilator, bradykinin Homo sapiens