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Literature summary for 3.4.15.1 extracted from

  • Erdoes, E.G.; Tan, F.; Skidgel, R.A.
    Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function (2010), Hypertension, 55, 214-220.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
additional information angiotensin converting enzyme inhibitors inhibit angiotensin II formation and affect the bradykinin B1 and B2 receptor, B2R and B2R, signaling, overview. They indirectly potentiate the actions of bradykinin and enzyme-resistant analogues of bradykinin on receptor BR2R, leading to increased release of arachidonic acid and NO, and they increase B2R action as allosteric enhancers, via their C-domain, inducing a conformational change in the enzyme. The inhibitors are useful in therapy of cardiovascular diseases, overview. The bradykinin B1 receptor is directly activated by ACE inhibitors, even in absence of ACE Homo sapiens
Teprotide from snake venom peptides Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane the greater part of ACE exists free in the extracellular space, while only few residues are cytosolic or transmembranal, ratio 25:1 Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
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 angiotensin II + His-Leu
-
 ?
additional information Homo sapiens complex formation witht e bradykinin B2 receptor ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
additional information complex formation witht e bradykinin B2 receptor Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More the N- and C-domains of ACE shows a deep active site cleft and a lid region that restrict access of substrates or inhibitors until a conformational change of the enzyme occurs, binding of ACE inhibitors to one domain can alter the other Homo sapiens

Synonyms

Synonyms Comment Organism
ACE
-
 Homo sapiens
angiotensin I-converting enzyme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ACE limits the stimulation of bradykinin receptors by degrading bradykinin, functions of the bradykinin B2 receptor, B2R, signaling, overview. Interaction of B2R and ACE or allosteric transmission occurs on the plasma membrane surface Homo sapiens