Literature summary for 3.4.15.1 extracted from

Desmoulins, P.O.; Burgaud, S.; Horspool, L.J.
Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat in healthy cats (2008), J. Vet. Pharmacol. Ther., 31, 349-358.

Search for more literature for 3.4.15.1

Inhibitors

Inhibitors	Comment	Organism	Structure
ramipril	plasma-ACE activity is almost completely abolished 0.5-2.0 h after treatment with ramipril (0.125, 0.25, 0.5, and 1.0 mg/kg), irrespective of the dose rate, significant inhibition of ACE activity of 54.7 to 82.6% (depending on the dosage) is still present 24 h after treatment, ramipril at a dose rate of 0.125 mg/kg once daily produces significant and long-lasting inhibition of ACE activity in healthy cats	Felis catus
ramiprilat	-	Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin I + H2O	Felis catus	-	angiotensin II + L-His-L-Leu	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin I + H2O	-	Felis catus	angiotensin II + L-His-L-Leu	-	?
hippuryl-L-His-L-Leu + H2O	-	Felis catus	hippuric acid + L-His-L-Leu	-	?

Synonyms

Synonyms	Comment	Organism
ACE	-	Felis catus
angiotensin-converting enzyme	-	Felis catus

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Release 2023.1 (January 2023)