Application | Comment | Organism |
---|---|---|
medicine | ACE inhibition is a therapeutic target in treating peripheral occlusive arterial disease | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
quinapril | 18 mg/kg quinapril per day feeding for 3 days significantly reduces blood plasma ACE activity by 80%, quinapril administration for 16 days greatly decreases blood plasma ACE activity by 88% with 18 mg/kg per day, ACE activities in the heart, lung, and skeletal muscles of the 16-day ACE-inhibition with 18 mg/kg per day are 9%, 16%, and 22% of the controls, respectively | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + L-His-L-Leu | - |
? | |
bradykinin + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + L-His-L-Leu | - |
? | |
bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Rattus norvegicus |
angiotensin converting enzyme | - |
Rattus norvegicus |
DCP | - |
Rattus norvegicus |