Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.15.1 extracted from

  • Riviere, G.; Michaud, A.; Corradi, H.R.; Sturrock, E.D.; Ravi Acharya, K.; Cogez, V.; Bohin, J.P.; Vieau, D.; Corvol, P.
    Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active (2007), Gene, 399, 81-90.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO-K1 cells Xanthomonas axonopodis

Inhibitors

Inhibitors Comment Organism Structure
captopril
-
Xanthomonas axonopodis
delaprilat weak Xanthomonas axonopodis
EDTA
-
Xanthomonas axonopodis
enalaprilat
-
Xanthomonas axonopodis
fosinoprilat
-
Xanthomonas axonopodis
lisinopril weak Xanthomonas axonopodis
perindoprilat weak Xanthomonas axonopodis

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasmic space XcACE is constituvely expressed and is likely to be secreted and further localised in the periplasmic space Xanthomonas axonopodis 42597
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc XcACE activity depends on zinc binding. Hydrolysis of 7-methoxycoumarin-4-yl-diacetyl-SDKP-N3 (2,4-dinitrophenyl)L-2,3-diaminopropionyl-OH is abolished after zinc chelation with EDTA and dialysis but is restored by zinc addition Xanthomonas axonopodis

Organism

Organism UniProt Comment Textmining
Xanthomonas axonopodis
-
pv. citri
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Xanthomonas axonopodis angiotensin II + His-Leu
-
?
hippuryl-His-Leu + H2O
-
Xanthomonas axonopodis hippuric acid + His-Leu
-
?

Synonyms

Synonyms Comment Organism
XcACE
-
Xanthomonas axonopodis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
-
Xanthomonas axonopodis fosinoprilat
0.00016
-
-
Xanthomonas axonopodis captopril