Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.15.1 extracted from

  • Deaton, D.N.; Graham, K.P.; Gross, J.W.; Miller, A.B.
    Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite (2008), Bioorg. Med. Chem. Lett., 18, 1681-1687.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid
-
Homo sapiens
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
-
Homo sapiens
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid
-
Homo sapiens
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
-
Homo sapiens
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid
-
Homo sapiens
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
Homo sapiens
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
Homo sapiens
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
Homo sapiens
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
-
Homo sapiens
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
-
Homo sapiens
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
-
Homo sapiens
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
-
Homo sapiens
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
-
Homo sapiens
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
-
Homo sapiens
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
Homo sapiens
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
Homo sapiens
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
Homo sapiens
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
Homo sapiens
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
Homo sapiens
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9BYF1 precursor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MCA-Ala-Ser-Asp-Lys-Dap(DNP)-OH + H2O angiotensin-converting enzyme Homo sapiens ?
-
?
MCA-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH + H2O angiotensin-converting enzyme 2 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Homo sapiens
ACE2
-
Homo sapiens
angiotensin-converting enzyme
-
Homo sapiens
angiotensin-converting enzyme 2
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000009
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000013
-
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000015
-
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000015
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000002
-
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000022
-
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000022
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000022
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000024
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000024
-
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000025
-
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000027
-
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000058
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000006
-
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.0000085
-
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000014
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000035
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000037
-
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.000084
-
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.00009
-
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
0.00018
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00025
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00025
-
[[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00031
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00041
-
(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00049
-
(2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00057
-
O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00057
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-phenylpropanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00075
-
3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.00077
-
2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH, angiotensin-converting enzyme Homo sapiens
0.00095
-
O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.001
-
(2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.0011
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.0018
-
O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.0018
-
(2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(1-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.0026
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.004
-
O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.005
-
N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme Homo sapiens
0.02
-
(2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
0.025
-
O-[3,5-bis(trifluoromethyl)benzyl]-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens