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Literature summary for 3.4.15.1 extracted from

  • Kiss, A.; Kowalski, J.; Melzig, M.F.
    Compounds from Epilobium angustifolium inhibit the specific metallopeptidases ACE, NEP and APN (2004), Planta Med., 70, 919-923.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ellagic acid IC50: 0.4 mM Sus scrofa
hyperosid IC50: 0.2 mM Sus scrofa
isoquercitrin IC50: 0.3 mM Sus scrofa
lisinopril IC50: 1 nM Sus scrofa
additional information compounds from Epilobium angustifolium inhibit. Taking into account the role of these peptidase in prostate diseases, the results may partly support and explain the use of Epilobium extracts in folk medicine Sus scrofa
oenothein B IC50: 0.25 mM Sus scrofa
quercetin 3-O-(6''-galloyl)-galactoside IC50: 0.16 mM Sus scrofa
quercitrin IC50: 0.25 mM Sus scrofa
quercitrin glucuronide IC50: 0.2 mM Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O
-
Sus scrofa hippuric acid + His-Leu
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
IC50: 1 nM Sus scrofa lisinopril
0.16
-
IC50: 0.16 mM Sus scrofa quercetin 3-O-(6''-galloyl)-galactoside
0.2
-
IC50: 0.2 mM Sus scrofa hyperosid
0.2
-
IC50: 0.2 mM Sus scrofa quercitrin glucuronide
0.25
-
IC50: 0.25 mM Sus scrofa quercitrin
0.25
-
IC50: 0.25 mM Sus scrofa oenothein B
0.3
-
IC50: 0.3 mM Sus scrofa isoquercitrin
0.4
-
IC50: 0.4 mM Sus scrofa ellagic acid